# CELL-CELL ADHESION MOLECULES IN DEVELOPMENT

> **NIH NIH R37** · CASE WESTERN RESERVE UNIVERSITY · 1994 · $279,350

## Abstract

DESCRIPTION (adapted from applicant's abstract): The objectives of this
investigator are to investigate the mechanism of action and biological
significance of cell-cell adhesion molecules (CAMs) during development
of the  vertebrate embryo.  The major focus of this work is the neural
cell adhesion  molecule (NCAM), which is a broadly distributed cell
surface protein whose  binding functions and unusual polysialic acid
(PSA) moiety influence a wide  variety of cell interactions.  A
multidisciplinary approach is proposed that  includes analyses of the
purified glycoprotein, membrane vesicles, cDNA  transfected cells, and
intact tissues from enzymatically or genetically  altered embryos.
Individual experiments focus on characterization of the  functional
domains of NCAM, on the regulated biosynthesis of PSA, as well as  an
analysis of the role of the NCAM polypeptide and PSA isoforms in a
variety  of well established developmental systems.

## Key facts

- **NIH application ID:** 2197638
- **Project number:** 2R37HD018369-11
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **SAM.gov UEI:** HJMKEF7EJW69
- **Principal Investigator:** URS S RUTISHAUSER
- **Activity code:** R37 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $279,350
- **Award type:** 2
- **Project period:** 1983-12-01 → 1998-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2197638

## Citation

> US National Institutes of Health, RePORTER application 2197638, CELL-CELL ADHESION MOLECULES IN DEVELOPMENT (2R37HD018369-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2197638. Licensed CC0.

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