# DEVELOPMENTAL POTENTIAL OF CELLS FROM THE NEURAL CREST

> **NIH NIH R01** · COLUMBIA UNIV NEW YORK MORNINGSIDE · 1994 · $179,017

## Abstract

DESCRIPTION (Investigator's Abstract):  This proposal will study the
restriction of developmental potential in the neural crest cells that form
the enteric nervous system.  This large and most complex division of the
peripheral nervous system is derived from a small number of precursor cells
that migrate along defined pathways from the vagal crest of the head and
the sacral crest of the pelvis.  Experiments done with previous support, in
which pieces of quail gut were transplanted into appropriate or
inappropriate crest migration pathways of younger chick hosts, revealed
that those crest-derived cells that first colonize the gut retain a
developmental potential that is greater than that which is ultimately
exhibited by these cells when they differentiate within the gut.  Targets
reached by these transplanted cells were appropriate for the sites in which
the enteric grafts were placed, and did not reflect the cell's previous
history.

The proposed experiments will further characterize the developmental
potential of these cells by purifying them via immunoselection using a
neural-crest specific antibody (NC-1) linked to magnetic beads.
Experiments, which transplant these purified cells back into younger host
embryos and grow them in culture, will determine:  1) whether the
properties of these cells are equivalent to those that migrate out of
intact gut segments; how their developmental potential changes as a
function of age and of their extent of migration; and 3) whether the
developmental potential of the vagal crest-derived cells is different from
that of sacral crest-derived cells.

## Key facts

- **NIH application ID:** 2198018
- **Project number:** 5R01HD020470-08
- **Recipient organization:** COLUMBIA UNIV NEW YORK MORNINGSIDE
- **SAM.gov UEI:** F4N1QNPB95M4
- **Principal Investigator:** TAUBE P ROTHMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $179,017
- **Award type:** 5
- **Project period:** 1987-03-01 → 1996-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2198018

## Citation

> US National Institutes of Health, RePORTER application 2198018, DEVELOPMENTAL POTENTIAL OF CELLS FROM THE NEURAL CREST (5R01HD020470-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2198018. Licensed CC0.

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