# CORTICOSTEROID AND THYROID EFFECTS ON LUNG MATURATION

> **NIH NIH R01** · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · 1994 · $110,215

## Abstract

We are seeking continued funding to ask a number of questions about
strategies to mature the fetal lung that have the potential to be applied
clinically.  We hypothesize that single dose, direct fetal administration
of hormones alone or in combination will cause rapid and large lung
maturational effects in fetuses that have not been previously
manipulated.  We plan to use hormones (corticosteroids, thyroid hormones,
EGF and TGF-alpha) only at doses and treatment durations that are
clinically relevant.  We will treat preterm sheep by ultrasound guided
direct fetal injections and then deliver the preterm lambs 48 hours
later.  The lambs will be evaluated extensively for postnatal pulmonary
adaptation over 4 hours.  Physiologic assessments will focus on
measurements that translate into improved lung function.  We will measure
lung volumes, compliances, gas exchange, edema formation, and the
responses of the lungs to surfactant treatment.  We also will measure
biochemical markers of lung maturation - alveolar and lung tissue
saturated phosphatidylcholine pool sizes, alveolar surfactant protein A
(SP-A), and SP-A, SP-B, and SP-C mRNA levels in lung tissue.  The goal
is to identify a simple, single dose treatment strategy that can include
agents not permeable to the placenta that will effectively and reliably
mature the fetal lung.

## Key facts

- **NIH application ID:** 2198052
- **Project number:** 5R01HD020618-09
- **Recipient organization:** LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
- **SAM.gov UEI:** LTJVF4QSFCP9
- **Principal Investigator:** Michael Glenn Ross
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $110,215
- **Award type:** 5
- **Project period:** 1985-09-01 → 1996-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2198052

## Citation

> US National Institutes of Health, RePORTER application 2198052, CORTICOSTEROID AND THYROID EFFECTS ON LUNG MATURATION (5R01HD020618-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2198052. Licensed CC0.

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