# PERINATAL EMPHASIS RESEARCH CENTER GRANT

> **NIH NIH P50** · CINCINNATI CHILDRENS HOSP MED CTR · 1994 · $536,302

## Abstract

The long-term objective of the Center is to optimize fetal and neonatal
growth and to decrease fetal and infant morbidity and mortality.  These
goals will be accomplished by defining and understanding the basic
physiology of fetal and neonatal growth and growth retardation.  The
overall thesis examined is that specific growth factors are principal
regulators of growth and development of the fetus and infant.  Drs. Tsang,
Clark, Handwerger, and Whitsett provide the administrative organizational
framework for the PERC.  The Molecular Core provides a central site for
molecular norphologic studies and training in in situ hybridization and
immunocytochemistry, directed by Dr. Jeff Whitsett.  Drs. Korfhagen and
Whitsett will identify a progenitor during branching morphogenesis and Type
II cytodifferentiation in the fetal lung.  Drs. Weaver and Drake will test
the hypothesis that the temporal and spatial regulation of pulmonary
glycogen metabolism, in the developing respiratory epithelium, is
correlated with the pre-translational regulation of glycogen synthase
(Project B) and phosphorylase kinase (Project A).  Dr. Lieberman examines
the thesis that injections of neonatal rats with epidermal growth factor
alters ontogenic expression of fibroblast growth factors (FGFs).  Drs.
Hoath and Donnelly test the thesis that perturbations of perinatal growth;
i.e. placental insufficiency or exposure to exogenous EGF, will alter
molecular events of early homeothermic adaptation in brown adipose tissue
and imprint aberrant patterns of metabolic function in adults.  Drs.
Chernausek and Smith examine the thesis that carrier proteins for insulin-
like growth factors are physiologically-regulated modulators of IGF action
during the perinatal period.  Dr. Iwamoto tests the hypothesis that the
placenta and fetal liver regulated plasma concentrations of IGF-I and thus
coordinate fetal growth.  Dr. Clark tests the thesis that chronic reduced
uteroplacental blood flow leads to asymmetric growth retardation and
reduced IGF-I by altering delivery and uptake of oxygen, glucose, and amino
acids by the placenta and fetus while also testing the thesis that direct
fetal supplementation with nutrients and maternal oxygen administration can
prevent IUGR.  Thus in this Center, molecular biologic, cellular,
physiologic, and a clinical study complement each other in an integrated
multidisciplinary study.

## Key facts

- **NIH application ID:** 2198077
- **Project number:** 5P50HD020748-09
- **Recipient organization:** CINCINNATI CHILDRENS HOSP MED CTR
- **SAM.gov UEI:** JZD1HLM2ZU83
- **Principal Investigator:** REGINALD C TSANG
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $536,302
- **Award type:** 5
- **Project period:** 1985-09-30 → 1996-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2198077

## Citation

> US National Institutes of Health, RePORTER application 2198077, PERINATAL EMPHASIS RESEARCH CENTER GRANT (5P50HD020748-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2198077. Licensed CC0.

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