# NEUROBEHAVIORAL DEFINITION AND SUBTYPING OF DYSLEXIA

> **NIH NIH P01** · WAKE FOREST UNIVERSITY · 1994 · $686,362

## Abstract

Continuation is proposed for three highly interrelated projects:

(a) a longitudinal behavioral study of normal, reading impaired, and "at
risk" samples which had been started in 1st grade, third grade, and
kindergarten, respectively;

(b) a family study of adult dyslexics (defined by childhood
psychometrics), including their spouses, siblings, parents, and children,
and using behavioral measurement of the phenotype for all subjects and
electrophysiological measurement of the phenotype for probands and their
children; and

(c) an integrated multidimensional physiological and anatomical study of
the dyslexic phenotype---using blood flow (rCBF), event related potentials
(ERP), positron emission tomography (PET), and magnetic resonance imaging
(MRI).

These studies are intended to clarify:

(a) the longitudinal course of normal and impaired reading, and the
differentiation of these courses from each other, including the
demonstration of phenotypic markers of emerging dyslexia distinct from
attention deficit disorder, low intelligence, and related conditions, and
the possible intra-linguistic subtyping of the dyslexic phenotype;

(b) the familial transmission patterns of the phenotype and its component
processes and related comorbid disorders such as ADHD.

(c) converging evidence for an anatomical (temporal planum; and
physiological (left temporal, left angular gyrus, left caudate) deficit as
characterizing the dyslexic phenotype.

## Key facts

- **NIH application ID:** 2198345
- **Project number:** 5P01HD021887-07
- **Recipient organization:** WAKE FOREST UNIVERSITY
- **SAM.gov UEI:** MBU6HCLNZ431
- **Principal Investigator:** Frank Balch Wood
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $686,362
- **Award type:** 5
- **Project period:** 1986-08-01 → 1998-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2198345

## Citation

> US National Institutes of Health, RePORTER application 2198345, NEUROBEHAVIORAL DEFINITION AND SUBTYPING OF DYSLEXIA (5P01HD021887-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2198345. Licensed CC0.

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