# MOLECULAR BASIS OF NORMAL AND MUTANT LIMB DEVELOPMENT

> **NIH NIH R01** · MASSACHUSETTS GENERAL HOSPITAL · 1994 · $355,852

## Abstract

The overall goal of the research is to understand the developmental
processes that take place in Chip embryonic limb. In this developmental
system, changes occur in the activity of a number of genes at the time of
differentiation of limb mesodermal cells into chondrocytes. We will study:
a) the structure-function relationship of the translation products of newly
activated genes in the establishment of the cartilaginous matrix, b) the
regulatory sequences that are specific for the expression of one of these
genes in chondrocytes and c) the morphogenetic consequences of induced and
spontaneous mutations that affect cartilage matrix macromolecules.

## Key facts

- **NIH application ID:** 2198406
- **Project number:** 5R01HD022016-11
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **SAM.gov UEI:** FLJ7DQKLL226
- **Principal Investigator:** PAUL F GOETINCK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $355,852
- **Award type:** 5
- **Project period:** 1986-01-01 → 1996-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2198406

## Citation

> US National Institutes of Health, RePORTER application 2198406, MOLECULAR BASIS OF NORMAL AND MUTANT LIMB DEVELOPMENT (5R01HD022016-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2198406. Licensed CC0.

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