# ESTROGEN REPLACEMENT AND COMPLICATIONS OF AMENORRHEA

> **NIH NIH R01** · ST. LUKE'S ROOSEVELT HOSP CTR (NEW YORK) · 1992 · $199,080

## Abstract

We have identified a deficiency in the exercise induced increase in bone
mass in stressed bones of premenopausal amenorrheic women. The lack of bone
strengthening which usually occurs in this setting appears to lead to an
increase in fracture rate particularly in women with delayed menarche. This
problem is of considerable importance to an exercising female population.
We wish to examine the effects of estrogen replacement in this group to
determine if this normal physiologic response can be reinitiated with
hormonal therapy. Sixty exercising amenorrheic ballet dancers will be
allocated randomly into two treatment groups: (A) estrogen treated, (B)
placebo. After two years treatment, the participants will continue in the
study for one year. The women will be randomized into four subgroups: (A)
hormone treated unchanged, (B) placebo treated unchanged, (C) hormone
treated to placebo, and (D) placebo to hormone treated. A control group of
25 normal dancers will be followed. All subjects will receive 10OOg
calcium/day during both studies. The response of the skeleton in exercising
women will thus be examined on estrogen replacement to determine if a
normal increase in bone mass occurs with therapy and determine of the
pattern persists after withdrawal of therapy. Injury rates in all groups
will be followed to determine if there is a relation to injury and compared
to normal controls on no medication. Further understanding of the role of
estrogen deficiency on the skeleton of the premenopausal exercising women
would radically alter attitudes towards the importance of therapy to
prevent injury and would lead to the formulation of effective treatment to
prevent stress fractures, particularly in a young population.

## Key facts

- **NIH application ID:** 2198470
- **Project number:** 5R01HD022171-07
- **Recipient organization:** ST. LUKE'S ROOSEVELT HOSP CTR (NEW YORK)
- **Principal Investigator:** MICHELLE P WARREN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $199,080
- **Award type:** 5
- **Project period:** 1986-08-01 → 1995-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2198470

## Citation

> US National Institutes of Health, RePORTER application 2198470, ESTROGEN REPLACEMENT AND COMPLICATIONS OF AMENORRHEA (5R01HD022171-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2198470. Licensed CC0.

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