# STRUCTURE AND FUNCTION OF THE LH/CG RECEPTOR

> **NIH NIH R01** · UNIVERSITY OF IOWA · 1994 · $198,800

## Abstract

The lutropin/choriogonadotropin receptor (LHR), present on the cell
surface of certain cells in the ovaries and testes, plays a critical role
in reproductive physiology. Recent studies from our lab and others on the
cloning of the cDNA for this receptor have shown that it is a member of
the family of G protein-coupled receptors and thus contains the
characteristic feature of seven membrane-spanning domains oriented with
the C-terminus on the cytoplasmic face. Unlike many other G protein-
coupled receptors, however, the LHR contains a large extracellular domain
which we and others have shown to be sufficient for high affinity binding
of hCG.

The focus of the present grant is to continue some studies that have
already begun and to initiate others that will yield information about the
structure and function relationships of the LHR and in turn on the
mechanism of action of the receptor. Specifically, the aims of the grant
are to:

A. Determine the sites of N-linked glycosylation on the rLHR and their
role, if any, on signal transduction

B. Continue studies on identifying regions of the rLHR which mediate
hormone-occupied receptor internalization

C. Identify regions of the rLHR involved in activating G proteins

D. Investigate the mechanisms of rLHR activation

The information learned from these studies will contribute to our
understanding of G protein-coupled receptors in general (which are
integral to various physiological systems) and more specifically will
further our understanding of the role of this receptor in reproductive
physiology. As such, it is anticipated that the results of these studies
will aid us in the future in understanding, diagnosing, and treating
certain forms of infertility, as well as in the design of novel
contraceptive agents to suppress fertility.

## Key facts

- **NIH application ID:** 2198476
- **Project number:** 2R01HD022196-10
- **Recipient organization:** UNIVERSITY OF IOWA
- **SAM.gov UEI:** Z1H9VJS8NG16
- **Principal Investigator:** DEBORAH SEGALOFF
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $198,800
- **Award type:** 2
- **Project period:** 1990-05-01 → 1999-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2198476

## Citation

> US National Institutes of Health, RePORTER application 2198476, STRUCTURE AND FUNCTION OF THE LH/CG RECEPTOR (2R01HD022196-10). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2198476. Licensed CC0.

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