# DEVELOPMENT OF SLEEP STATES AND SIDS RISK

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1994 · $138,424

## Abstract

This project will examine the development of physiological measures and
sleep states in normal infants and in infants at risk for the sudden infant
death syndrome (SIDS).  The objective is to find physiological
characteristics that differentiate infants who later succumbed from those
who survived, and apply these characteristics to a yet-unexamined group at
risk for SIDS.  Infants who later succumbed to SIDS, and two groups of
infants at increased risk of SIDS, siblings of SIDS victims and infants who
experienced a life-threatening event, will be compared with age-matched
controls using data already collected.  The objectives are based on the
assumptions 1) that SIDS victims succumb from a failure of mechanisms that
normally allow a state transition when the infant is exposed to a life-
threatening challenge, and 2) that physiological signs, measured during
different states, will provide suggestions of the mechanisms that lead to a
failure to respond adequately to challenges.  Instantaneous and long term
changes in cardiac and respiratory intervals, obtained during each sleep-
waking state, will be assessed over the first 6 months of life in normal
infants and AIDS-siblings, and in single recordings of infants who
experienced a life threatening event or subsequently died of SIDS.  The
interaction between physiological variables that define sleep states will
be assessed using linear time-domain filtering procedures and frequency-
domain spectral techniques, together with nonlinear dynamic procedures
including phase-plane plots, to determine if development of moment-to-
moment activity and interactions between variables are altered in infants
at risk.  The temporal characteristics of sleep-walking states, including
distribution of states across the night, state transition probabilities,
periodic organization, and time of night modulation of sleep and waking
physiology will be compared between control infants and infants at risk.
Relationships of moment-to-moment physiological alterations in activity to
the 3-4 h "feeding rhythm" and to time-of-night will be quantified for each
group.  Assessment of instantaneous variation in cardiac and respiratory
intervals will include Poincare procedures and phase-plane plots, together
with ANOVA assessment of dispersion at different rates.  Multivariate
statistical procedures, including stepwise logistic regression and
discriminant analysis, will also be used to assess differences among risk
groups.

## Key facts

- **NIH application ID:** 2198642
- **Project number:** 5R01HD022695-09
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **SAM.gov UEI:** RN64EPNH8JC6
- **Principal Investigator:** RONALD Marven HARPER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $138,424
- **Award type:** 5
- **Project period:** 1986-12-01 → 1997-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2198642

## Citation

> US National Institutes of Health, RePORTER application 2198642, DEVELOPMENT OF SLEEP STATES AND SIDS RISK (5R01HD022695-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2198642. Licensed CC0.

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