# GENETICS OF HEDGEHOG AND ADJACENT LOCI OF DROSOPHILA

> **NIH NIH R01** · BARNARD COLLEGE · 1994 · $90,123

## Abstract

The research proposed in this grant addresses the question of how genes
control the process of pattern formation in developing embryos.  This
research will determine the role of the hedgehog gene of Drosophila in
establishing the parasegmental boundary, which is one of two
developmental field boundaries established during segmentation of the
early Drosophila embryo.  The pattern of expression of hedgehog, as
judged by immunohistochemistry, will be compared with that of other
segment polarity genes involved in this process, both during the
establishment of this boundary in embryogenesis and in its maintenance
in the imaginal discs.  Controls on the regulation of hedgehog
expression, both in establishing and maintaining its spatial expression
pattern (as judged by the distribution of its RNA and protein products)
and on the developmental regulation of splicing of the hedgehog RNA, will
be investigated.  Finally, the nature of the hedgehog product, and the
identification of possible roles of the gene's function, will be
identified by isolation and sequencing of complete cDNAs from the
hedgehog locus.

## Key facts

- **NIH application ID:** 2198655
- **Project number:** 5R01HD022751-07
- **Recipient organization:** BARNARD COLLEGE
- **SAM.gov UEI:** LPQ1NHRK78M9
- **Principal Investigator:** JAMES P MOHLER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $90,123
- **Award type:** 5
- **Project period:** 1988-02-01 → 1998-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2198655

## Citation

> US National Institutes of Health, RePORTER application 2198655, GENETICS OF HEDGEHOG AND ADJACENT LOCI OF DROSOPHILA (5R01HD022751-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2198655. Licensed CC0.

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