# INSULIN RESISTANCE AND GLUCOSE METABOLISM IN PREGNANCY

> **NIH NIH R01** · CASE WESTERN RESERVE UNIVERSITY · 1994 · $143,463

## Abstract

The long term objective of this application is to examine the importance
of progravid maternal insulin sensitivity on the maternal metabolic
adaptations during pregnancy.  The specific aims of the proposal are 1)
to characterize the longitudinal changes in maternal carbohydrate
metabolism in obese control subjects and obese women with gestational
diabetes prior to conception and in early and late gestation and 2) to
determine if the changes in maternal energy expenditure and body
composition in early gestation are related to alterations in maternal
carbohydrate metabolism.  We plan to achieve the first specific aim by
longitudinally evaluating 7 obese women subjects will be evaluated using:
1) the oral glucose tolerance test, 2) intravenous glucose tolerance
test, 3) hydrodensitometry, and 4) a low and high dose hyperinsulinemic-
euglycemic clamp coupled with glucose infusion.  The specific methodology
will allow evaluation of: 10 insulin response, 2) basal endogenous
glucose production and suppression with a low and high insulin infusion
and 3) calculation of an insulin sensitivity slope.  We plan to achieve
the second specific aim by evaluating the 14 subjects described in the
first specific aim and 7 additional lean subjects prior to conception and
in early gestation using the same specific methodology in the first
specific aim plus: 1) indirect calorimetry, 2) hydrodensitometry
corrected for total body water and 3) doubly labelled water.  The
specific methodology will allow us to evaluate 1) energy expenditure in
the basal state and during insulin infusion, 2) the route of glucose
disposal, i.e. oxidative vs non-oxidative, 3) maternal body composition
and 4) total energy expenditure in the free living state over 12 days.
The information obtained from theses studies will provide us with the
information to develop clinical methodologies to diagnose and treat
gestational diabetes earlier in gestation based on the specific metabolic
abnormality.

## Key facts

- **NIH application ID:** 2198719
- **Project number:** 2R01HD022965-07A1
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **SAM.gov UEI:** HJMKEF7EJW69
- **Principal Investigator:** Patrick Catalano
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $143,463
- **Award type:** 2
- **Project period:** 1987-06-02 → 1997-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2198719

## Citation

> US National Institutes of Health, RePORTER application 2198719, INSULIN RESISTANCE AND GLUCOSE METABOLISM IN PREGNANCY (2R01HD022965-07A1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2198719. Licensed CC0.

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