# SEVERE PREMENSTRUAL SYNDROMES: RISK/COURSE/MECHANISMS

> **NIH NIH R01** · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · 1994 · $188,744

## Abstract

The work proposed for this renewal application continues to have the
long-term aim of better understanding the nature and course of severe
premenstrual syndromes.  The studies are focused upon efforts to
prospectively identify characteristics of women who are vulnerable to the
development of severe or extreme premenstrual problems and to better
understand the natural history and correlates of premenstrual syndromes
with different clinical characteristics.  The findings have the potential
to help guide clinical practice and planning to help focus efforts to
determine the pathophysiology of severe premenstrual problems.

      Components specific aims are:
1. Identify characteristics of prior history and intake status that are
(a) correlated with severe premenstrual dysphoric mood changes and
functional impairment and (b) predictive of their subsequent development.

2. Identify the pattern of interactions between prior history and intake
characteristics and intervening variables which might increase the risk
for development of severe premenstrual syndromes (e.g., pregnancy, use of
oral contraceptives, life stress).

3. Determine, prospectively, the relationship between severe premenstrual
syndromes and severe dysphoric changes at other periods of hormonal
change (miscarriage, childbirth, menopause).

4. Determine, prospectively, the degree to which premenstrual problems
increase the risk for development of episodic or chronic mental or other
medical disorders.

5. Determine the stability, or instability, of levels of severity of
different types of premenstrual mood, behavioral, and physical changes.

6. Try to identify intervening variable that might help account for a
lessening of severity of premenstrual problems (e.g., treatment, changes
in levels of stress or life-style).

The proposed studies involve continued follow-up evaluations of women who
at intake had no current physical or mental disorder, who were without
problems during the follicular phase of the menstrual cycle and were
characterized by having either: (1) no or only mild premenstrual changes
in mood, behavior, or physical condition and no functional impairment; or
(2) moderate premenstrual changes in mood and behavior and some
functional impairment but no history of ever having sought treatment for
these changes; or (3) distinct and severe or extreme premenstrual
syndromes characterized by anxiety, irritability, or depression and
functional impairment associated with these changes.

## Key facts

- **NIH application ID:** 2198890
- **Project number:** 5R01HD023512-07
- **Recipient organization:** NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- **SAM.gov UEI:** TYVNMW8FNQQ3
- **Principal Investigator:** JEAN ENDICOTT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $188,744
- **Award type:** 5
- **Project period:** 1988-02-01 → 1998-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2198890

## Citation

> US National Institutes of Health, RePORTER application 2198890, SEVERE PREMENSTRUAL SYNDROMES: RISK/COURSE/MECHANISMS (5R01HD023512-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2198890. Licensed CC0.

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