# NEUROPATHOLOGY AND BRAIN DEVELOPMENT IN PEDIATRIC AIDS

> **NIH NIH R01** · INSTITUTE FOR BASIC RES IN DEV DISABIL · 1993 · $130,974

## Abstract

Human Immunodeficiency Virus (HIV) in addition to its profound effect on
the immune system has been shown to produce a primary and persistent
infection of the Central Nervous System (CNC) with relentlessly
progressive encephalopathy. The sequelae of this infection are
particularly devastating in the pediatric age group. HIV infection in
infants and children leads to microcephaly and brain atrophy.
Opportunistic CNS infections in pediatric AIDS are rare. The mechanisms
of cellular damage and the cell population in the CNS which is primarily
damaged by HIV are still not known. The objective of this study is to
define the effect of HIV infection on a developed and on a developing
brain; to define the extent of CNS atrophy/microcephaly; and to determine
which brain cell populations are affected in pediatric AIDS. Brains
obtained at autopsy from infants and children with AIDS infected with HIV
either in utero, or postnatally by blood transfusion or with blood
products, and the brains from non-AIDS age-matched control cases will be
evaluated neuropathologically. Histological, stereological, morphometric
and immunocytochemical methods will be used. The information from this
study will contribute to a better understanding of the effect of HIV
infection of the developing human brain and for better clinico-
pathological definition of HIV encephalopathy in pediatric AIDS.

## Key facts

- **NIH application ID:** 2199335
- **Project number:** 5R01HD024884-05
- **Recipient organization:** INSTITUTE FOR BASIC RES IN DEV DISABIL
- **SAM.gov UEI:** LKEPMM3KKF27
- **Principal Investigator:** PIOTR B KOZLOWSKI
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $130,974
- **Award type:** 5
- **Project period:** 1988-12-01 → 1995-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2199335

## Citation

> US National Institutes of Health, RePORTER application 2199335, NEUROPATHOLOGY AND BRAIN DEVELOPMENT IN PEDIATRIC AIDS (5R01HD024884-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2199335. Licensed CC0.

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