# REGULATION OF THE PRIMATE CORPUS LUTEUM

> **NIH NIH R01** · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 1992 · $102,896

## Abstract

The corpus luteum (CL) plays a major role in the primate reproductive
process. The hormones produced by the CL are necessary for the successful
implantation of the ovum in the uterus and hence a successful pregnancy.
Little is known about the mechanisms involved in the control of this
"endocrine" gland. Recent evidence indicates that several gonadal
peptides one of which is oxytocin (OT) may be involved in luteal
development. Using the baboon as an experimental model the objectives of
this study are a) to evaluate the effects of prostaglandin F2a on CL
hormone production, b) to examine the effect of OT and hCG on PGF, 6-
ketoprostaglandin F1a and 5-HETE production. These effects will be
examined using an in vitro dispersed cell preparation, in short term
incubations (3 hr), long term (24-48 hr) culture and in vivo using local
infusion techniques, c) to examine the exact site in the steroidogenic
pathway where OT may have its effect, d) to determine if the action of OT
is receptor mediated, using CL membrane preparations and autoradiography,
e) to measure PGF 2a receptors using CL membrane preparation and f) to
determine if ovarian OT is biologically active using an in vitro
bioassay. The hormones in the media from the in vitro studies and in
blood (femoral ovarian veins, contralateral to the CL and ipsilateral
vein) will be assayed by radioimmunoassay. Enzyme assays will be used to
determine the site of action of OT in corpus luteum steroidogenesis. The
data obtained will provide a more integrated picture of the mechanisms
controlling the primate CL which may permit new approaches to fertility
regulation as well as a better understanding of therapy of early
reproductive failures or difficulties due to ovulatory or corpus luteum
dysfunction. Similarly it may enable new approaches to the treatment of
menstrual dysfunction.

## Key facts

- **NIH application ID:** 2199349
- **Project number:** 5R01HD024928-04
- **Recipient organization:** UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- **SAM.gov UEI:** ZUFBNVZ587D4
- **Principal Investigator:** FIRYAL S KHAN-DAWOOD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $102,896
- **Award type:** 5
- **Project period:** 1990-04-01 → 1994-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2199349

## Citation

> US National Institutes of Health, RePORTER application 2199349, REGULATION OF THE PRIMATE CORPUS LUTEUM (5R01HD024928-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2199349. Licensed CC0.

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