# MOLECULAR BIOLOGY OF NEUROGENESIS

> **NIH NIH R01** · UNIV OF NORTH CAROLINA CHAPEL HILL · 1994 · $188,374

## Abstract

This proposal seeks to understand how regulatory genes control CNS
development.  Specifically, it explores the regulation and function of
the single-minded gene, which controls the formation of a group of
neurons and glia that lie along the midline of the Drosophila CNS.  Genes
that control dorsal-ventral patterning activate single-minded
transcription specifically in the midline precursor cells. single-minded
then activates transcription of a large group of genes that carry-out the
CNS midline lineage developmental program.  Sequence analysis indicates
that single-minded belongs to the basic-helix-loop-helix family of
transcription factors, which includes regulators of nervous system and
muscle development as well as growth control, carcinogen metabolism, and
sex determination.  In this grant, we will investigate how single-minded
controls midline gene expression at the biochemical level.  Additionally,
the role of genes shown by genetics to influence single-minded
transcription will be investigated using biochemistry and germline
transformation.

## Key facts

- **NIH application ID:** 2199461
- **Project number:** 5R01HD025251-07
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **SAM.gov UEI:** D3LHU66KBLD5
- **Principal Investigator:** Stephen T Crews
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $188,374
- **Award type:** 5
- **Project period:** 1993-10-01 → 1997-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2199461

## Citation

> US National Institutes of Health, RePORTER application 2199461, MOLECULAR BIOLOGY OF NEUROGENESIS (5R01HD025251-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2199461. Licensed CC0.

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