# SEX HORMONES IN NEUROCOGNITIVE DEVELOPMENT

> **NIH NIH R01** · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 1993 · $119,514

## Abstract

The relative roles of hormones and psychosocial factors on sex
specific behaviors have been explored in both animals and humans.
Recently, considerable attention has focused on differences between the
sexes In cognitive abilities, such as spatial versus verbal information
processing.  These abilities have been purported to be related to the
lateralized functional organization of the cerebral hemispheres.  From
these studies and from clinical neuropsychological studies it has been
suggested that male and female brains are organized differently.
Prenatal and postnatal exposure to sex hormones are believed to play a
significant role in these neurocognitive differences between the sexes.
The proposed investigation, will explore the potential relationship
between early sex hormone exposure and neurocognitive functioning.
     The present proposal has two major purposes: The first Is to study
the possible role of prenatal/prepubertal sex hormones on cognitive
abilities and electrophysiological Indices of cerebral functional
organization.  This goal will be accomplished through the study of Turner
Syndrome US) and normal pre pubertal female and male subjects.  The TS
and normal female and male subjects provide differing prenatal sex
hormone exposed groups.  TS females typically lack normal exposure to
prenatal sex hormones, whereas normal females and males are exposed to
different levels of prenatal estrogens and androgens.  By studying these
groups with different prenatal exposure to hormones, theoretical
questions can be addressed pertaining to the role of these hormones on
brain organization and on the development of cognition in the human.
     The second major purpose Is to develop a neurobehavioral profile of
TS individuals, to examine Individual differences in cognitive,
neurophysiological and psychosocial variables and to relate ability to
process social affective information to psychosocial variables, such as
self concept and behavioral adjustment.  This work should provide a
better understanding of the potential role of prenatal hormones In
neurocognitive functioning as well as a much more complete understanding
of the relationship between genotype and neurocognitive factors In TS
women.  Such information could, serve as a basis for early detection of
strengths and weaknesses in TS women and thereby lead to improved
educational approaches In this population as well as in other children
with learning difficulties.

## Key facts

- **NIH application ID:** 2199684
- **Project number:** 5R01HD025718-03
- **Recipient organization:** STATE UNIVERSITY OF NEW YORK AT BUFFALO
- **SAM.gov UEI:** LMCJKRFW5R81
- **Principal Investigator:** DAVID W SHUCARD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $119,514
- **Award type:** 5
- **Project period:** 1991-07-15 → 1995-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2199684

## Citation

> US National Institutes of Health, RePORTER application 2199684, SEX HORMONES IN NEUROCOGNITIVE DEVELOPMENT (5R01HD025718-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2199684. Licensed CC0.

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