# CHARACTERIZATION OF THE PROSTAGLANDIN F2A RECEPTOR

> **NIH NIH R01** · UNIVERSITY OF COLORADO DENVER · 1993 · $104,851

## Abstract

The prostaglandins belong to a large group of naturally occurring paracrine
mediators of physiologic responses.  One of the prostaglandins,
prostaglandin F 2alpha (PGF 2alpha), is important in responses such as:
myometrial contraction, bronchoconstriction, luteolysis, movement of the
egg/zygote through the oviduct, and growth of endometrial and osteoblastic
cells.  PGF 2alpha may also be one of the paracrine factors through which
estrogen elicits its effects on the uterus, ovary and breast.  As such,
abnormalities in the normal functioning of PGF 2alpha, or of its naturally
occurring antagonist prostaglandin E, could be responsible for altered
states of uterine contraction, bronchoconstriction, fertility, or growth of
uterus and bone.  I believe that a better biochemical characterization of
the PGF 2alpha receptor and elucidation of the control of expression of the
gene that codes for this receptor would facilitate understanding of how
this prostaglandin achieves those normal physiologic functions for which it
is responsible.  Similarly, it may help us understand the role of PGF
2alpha in diseases such as dysmenorrhea (PMS), endometrial hyperplasia,
ovarian cancer and infertility, among others.  Therefore, the specific aims
to be addressed in this grant are the continued development of the anti-PGF
2alpha receptor antibody tool and its use in immunohistochemical and
immunoprecipitation studies and in isolating the cDNA for the PGF 2alpha
receptor.  This PGF 2alpha receptor CDNA will then be sequenced providing
the amino acid sequence of the receptor as well as a hint of its structural
and enzymatic properties.  The PGF 2alpha receptor cDNA will also be used
as a tool to measure PGF 2alpha receptor mRNA levels in normal and hormonal
stimulated tissues.

## Key facts

- **NIH application ID:** 2199781
- **Project number:** 5R01HD025961-05
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **SAM.gov UEI:** MW8JHK6ZYEX8
- **Principal Investigator:** DAVID J ORLICKY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $104,851
- **Award type:** 5
- **Project period:** 1989-08-01 → 1995-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2199781

## Citation

> US National Institutes of Health, RePORTER application 2199781, CHARACTERIZATION OF THE PROSTAGLANDIN F2A RECEPTOR (5R01HD025961-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2199781. Licensed CC0.

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