# DEVELOPMENT OF CHILDREN WITH CRANIOFACIAL ANOMALIES

> **NIH NIH R01** · SEATTLE CHILDREN'S HOSPITAL · 1994 · $270,785

## Abstract

This competing renewal application proposes to continue a
longitudinal study of 62 infants and toddlers with craniofacial
anomalies (CFA) and a matched control group of 70 nonimpaired,
healthy children into their school-age years (ages 5, 6 and 7). The
CFA sample contains 3 types of disorders: Cleft lip and palate
(CLP), isolated cleft palate (CP) and sagittal synostosis (SAG).
This sample is now being assessed at ages 3, 12 and 24 months
(NICHHD R01 HD25987).  The current and proposed projects were
designed to develop a multifactorial risk profile that would allow
for the earliest possible detection of children with CFA at risk
for later psychological maladjustment and/or school failure.

This research is organized in relation to a developmental model
with selected predictor variables (e.g., attachment, medical
factors, family ecology) and child outcome variables (e.g.,
behavioral adjustment, peer status, school achievement).  This
research has 3 specific aims: l) To compare school-aged children
with and without CFA on selected predictor 5, 6 and 7; 2) To
compare these groups on selected outcome variables during the same
age period; and 3) To determine the relative contribution of
selected predictor variables to school-age outcomes for children
with CFA.

Among the hypotheses to be tested, we predict that group
differences will be found in language skills, parent-child
interactions, and parental emotional status and social support (all
favoring the control group).  By age 7, we anticipate that children
with CLP/CP will have lower school achievement and poorer
psychological outcomes. However, we expect attachment security to
"moderate" the adverse effects of these disorders on later
development. Finally, some aspects of mother-child interaction are
expected to predict school achievement, even after variation in
child neuropsychological ability is considered.  Hypotheses will be
tested with data gathered from observations, questionnaires and
tests, and subjected to multivariate analyses of variance,
regression models, and growth curve analyses.

## Key facts

- **NIH application ID:** 2199799
- **Project number:** 2R01HD025987-05
- **Recipient organization:** SEATTLE CHILDREN'S HOSPITAL
- **SAM.gov UEI:** SZ32VTCXM799
- **Principal Investigator:** MATTHEW Louis SPELTZ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $270,785
- **Award type:** 2
- **Project period:** 1989-09-01 → 1999-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2199799

## Citation

> US National Institutes of Health, RePORTER application 2199799, DEVELOPMENT OF CHILDREN WITH CRANIOFACIAL ANOMALIES (2R01HD025987-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2199799. Licensed CC0.

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