# SPONTANEOUS ABORTION AND AMNIOTIC FLUID INFECTION

> **NIH NIH R29** · UNIVERSITY OF WASHINGTON · 1994 · $51,311

## Abstract

A labor complicated by amniotic fluid infection may have severe
consequences for the mother and neonate. Two reports have indicated that
women having a spontaneous abortion have an increased risk in the next
pregnancy of labor complicated by amniotic fluid infection. The purpose of
the proposed study is to determine the risk of amniotic fluid infection in
the next pregnancy among women who had a spontaneous abortion in the
immediately preceding pregnancy. The study will also determine whether an
intervening normal pregnancy or a long interpregnancy interval may reduce
the risk. The increased frequency of amniotic fluid infection after a
spontaneous abortion may result from an unresolved maternal lower or upper
genital tract infection which may have been the cause or a result of the
spontaneous abortion. The proposed study will evaluate factors which may
modify the relationship between spontaneous abortion and amniotic fluid
infection; postabortal infection, gestational age at abortion, suction or
instrument curettage after abortion, two or more successive abortions,
pelvic inflammatory disease or genital tract infections before or after the
abortion. These issues will be evaluated in a multi_hospital, case-control
study of 1360 women with amniotic fluid infection in their present
pregnancy compared to a equal sized control group. The cases will be
identified at six collaborating hospitals in King County, WA which treat
80% of the women delivering in the county. Controls will be frequency
matched to cases for hospital and month of delivery. Study participants
will have a medical record review
of their present pregnancy and a detailed structured interview focusing on
their prior pregnancies. The proposed study may determine that women having
spontaneous abortions may need to be identified, evaluated for genital
tract infections, and possibly treated, before attempting future
pregnancies.

## Key facts

- **NIH application ID:** 2199917
- **Project number:** 5R29HD026377-05
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **SAM.gov UEI:** HD1WMN6945W6
- **Principal Investigator:** Marijane Alberta Krohn
- **Activity code:** R29 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1994
- **Award amount:** $51,311
- **Award type:** 5
- **Project period:** 1990-08-01 → 1995-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/2199917

## Citation

> US National Institutes of Health, RePORTER application 2199917, SPONTANEOUS ABORTION AND AMNIOTIC FLUID INFECTION (5R29HD026377-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/2199917. Licensed CC0.

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