# GASTRIC MUCOSAL INJURY AND AGING

> **NIH NIH R01** · WAYNE STATE UNIVERSITY · 1991 · $108,916

## Abstract

Many studies have documented rapid recovery of the gastric mucosa following
minor to moderate injury, yet little is known about the intracellular
mechanisms responsible for healing, or whether mucosal regeneration is
affected by aging.  On the basis of our preliminary data we hypothesize
that (a) aging is associated with diminished regenerative capacity, and
that (b) this may in part be due to decreased activation of tyrosine
kinases (Tyr-k) and a reduction in tyrosine-specific phosphorylation of
regulatory proteins, specifically the epidermal growth factor receptor
(EGF-R), which possesses Tyr-k activity, and (c) this results in decreased
transcription of regulatory genes, leading to (d) diminished cell
proliferation and epithelial regeneration.

We now propose using the in vivo model of hypertonic saline-induced injury
in the Fischer-344 rats to determine (1) whether the age-related
differences in mucosal regeneration could be due to alterations in mucosal
proliferative activity, cell proliferation and migration, and (2) whether
the differences in cell proliferation are the result of age-related changes
in the rate of mucosal cell loss, and (3) whether the changes in cell
proliferation/cell migration correlate with histologic restitution of the
mucosa; (4) furthermore, we will also evaluate the role of tyrosine
kinases, specifically the 170 kDa phosphotyrosine membrane protein (which
we have tentatively identified as EGF-R) in the regulation of gastric
mucosal cell proliferation during regeneration.  Finally, (5) we will
determine whether the age-related changes in mucosal regeneration are under
the control of the proto-oncogene c-erbB-1 which encodes a truncated EGF-R
containing the cytoplasmic kinase domain.

The information derived from these studies has the potential to expand our
understanding of regenerative processes of the gastric mucosa and to
identify some of the mechanisms that may be responsible for maintaining
mucosal integrity.

## Key facts

- **NIH application ID:** 3120049
- **Project number:** 1R01AG008438-01A2
- **Recipient organization:** WAYNE STATE UNIVERSITY
- **SAM.gov UEI:** M6K6NTJ2MNE5
- **Principal Investigator:** ADHIP P. N. MAJUMDAR
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $108,916
- **Award type:** 1
- **Project period:** 1991-07-01 → 1995-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3120049

## Citation

> US National Institutes of Health, RePORTER application 3120049, GASTRIC MUCOSAL INJURY AND AGING (1R01AG008438-01A2). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3120049. Licensed CC0.

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