# ANTIOXIDANT ENZYMES AND AGING IN TRANSGENIC DROSOPHILA

> **NIH NIH R01** · SOUTHERN METHODIST UNIVERSITY · 1989 · $154,621

## Abstract

The general goal of the prospective studies is to understand the
causes of the aging process in animals.  Endogenously-generated
oxygen free radicals have been widely postulated to play a causal
role in the aging process; however, critical studies testing the
validity of this hypothesis have not as yet been conducted.  The
purpose of the proposed experiments is to determine if oxidative
stress is a causal factor in governing the rate of aging in
Drosophila melanogaster, using a molecular genetic approach.  The
effect of overexpression of antioxidant genes for superoxide
dismutase, catalase and seleno-dependent glutathione peroxidase,
either alone or in combination, on life span and age-related
changes in Drosophila will be examined.  Because the overexpression
on one antioxidant gene may create a biochemical imbalance in the
inter-related defense mechanisms, a major effort will be made to
construct transgenic strains with balanced antioxidant defenses.
Results of this study should indicate if the primary enzymatic
defense against partially reduced oxygen species are a causal
factor in the aging process of Drosophila.

## Key facts

- **NIH application ID:** 3120086
- **Project number:** 1R01AG008459-01
- **Recipient organization:** SOUTHERN METHODIST UNIVERSITY
- **SAM.gov UEI:** D33QGS3Q3DJ3
- **Principal Investigator:** RAJINDAR S SOHAL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $154,621
- **Award type:** 1
- **Project period:** 1989-07-01 → 1994-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3120086

## Citation

> US National Institutes of Health, RePORTER application 3120086, ANTIOXIDANT ENZYMES AND AGING IN TRANSGENIC DROSOPHILA (1R01AG008459-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3120086. Licensed CC0.

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