# AMYLOID DEPOSITION ALZHEIMER'S DISEASE

> **NIH NIH R01** · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 1992 · $170,000

## Abstract

Amyloid deposition in the brain is considered to be a marker for
Alzheimer's disease, although a causal relationship has not been proven.
The amyloid protein has not been available for study due to practical
problems with its purification.  In addition, current biophysical methods
are not suited for the characterization of insoluble, noncrystalline
proteins such as the amyloid proteins.  Our work has focussed on these two
problems.  We have been successful in developing a synthetic route to the 0
protein which is amenable to scale-up.  A novel biophysical approach
(solid-state NMR and FTIR) has allowed us to observe details in amyloid
structure which have heretofore escaped detection.  We propose to continue
the development of this approach.  Our goal is to fully determine the
molecular structure of the protein amyloid.

We also are interested in using this structural information to design
molecules which bind to amyloid (analogs of Congo red) and/or inhibit
amyloid formation (conformationally-restrained peptide analogs).  Finally,
we hope to determine the sequence requirements for amyloid formation by
comparing sequences from various amyloid-forming proteins.

## Key facts

- **NIH application ID:** 3120100
- **Project number:** 2R01AG008470-04
- **Recipient organization:** MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- **SAM.gov UEI:** E2NYLCDML6V1
- **Principal Investigator:** PETER T LANSBURY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $170,000
- **Award type:** 2
- **Project period:** 1989-07-12 → 1996-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3120100

## Citation

> US National Institutes of Health, RePORTER application 3120100, AMYLOID DEPOSITION ALZHEIMER'S DISEASE (2R01AG008470-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3120100. Licensed CC0.

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