# GRAFTING GENETICALLY MODIFIED CELLS TO THE BRAIN

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 1990 · $272,293

## Abstract

Neuronal grafting into the CNS has recently been suggested as a
potential approach to CNS therapy through the selective replacement
of cells lost as a function of disease or damage.  Independently,
studies aimed at direct genetic therapy in model systems have
recently begun to suggest conceptually new approaches to the
treatment of several kinds of human genetic diseases, especially
those caused by single gene deficiencies.  We have recently
suggested that a combination of these two approaches, namely the
grafting into the CNS.  We have presented evidence for the
feasibility of this approach, including a description of some
current techniques for mammalian cell gene transfer and CNS
grafting.  In this application we propose to test the phenotypic
effects of implanting cells expressing on of 2 vitally transduced
genes - the E. coli B-galactosidase (ladZ gene product) to optimize
conditions for grafting, and mouse Nerve Growth Factor (NGF) to
establish a phenotypic effect in young animals with brain damage,
or aged animals with morphological and cognitive deficits.

## Key facts

- **NIH application ID:** 3120185
- **Project number:** 5R01AG008514-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **SAM.gov UEI:** UYTTZT6G9DT1
- **Principal Investigator:** FRED H GAGE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $272,293
- **Award type:** 5
- **Project period:** 1989-07-01 → 1992-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3120185

## Citation

> US National Institutes of Health, RePORTER application 3120185, GRAFTING GENETICALLY MODIFIED CELLS TO THE BRAIN (5R01AG008514-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3120185. Licensed CC0.

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