# TRIAL OF HYPO TENSIVE VS. NORMOTENSIVE ANESTHESIA

> **NIH NIH R01** · HOSPITAL FOR SPECIAL SURGERY · 1992 · $187,180

## Abstract

Specific aims: is randomized trial will assess the impact of hypotensive
versus normotensive anesthesia on cognitive, cardiac and renal
complications in an elderly population undergoing total hip replacement.
Secondly, this trial will document and comprehensively assess the incidence
of persistent, post-operative josses in cognitive function in an elderly
population undergoing elective non-cardiac surgery.  Thirdly, this trial
will assess the impact of deliberate hypotensive anesthesia on
intraoperative blood loss and the need for non-autologous transfusions in
this population.

Experimental design and methods: A prospective randomized trial in elderly
patients with comorbid medical conditions undergoing elective total hip
replacement assessing the effect of hypotensive vs normotensive anesthesia
on the outcomes of cardiac, renal and cognitive complications.  Baseline
clinical and demographic data and comprehensive intra-operative monitoring
data will be collected and analyzed.  Occurrence of persistent
deterioration of performance will be assessed in three cognitive domains of
linguistic, psychomotor/attention, and memory function.  Outcome will be
measured by intrasubject comparison of psychometric test results three
months post-operatively versus pre-operatively.  Occurrence of major
cardiac and renal complications will be evaluated using a sensitive
surveillance protocol to detect perioperative myocardial infarction,
pulmonary edema, pulmonary emboli, congestive heart failure, and renal
injury.  The administrator of the cognitive tests, the co-investigators
assessing and reviewing post-operative cardiac outcomes, and the
coinvestigators reviewing and analyzing the cognitive test results will be
blinded to the type of anesthesia intervention.  Functional impact will be
assessed with an evaluative scale administered pre-operatively and three
months post-operatively.  The results of the functional scale will be
correlated with the results of serial psychometric testing to provide a
context in which changes on psychometric tests can be interpreted.

Long term objective: The long term objective is to assess the risks and
benefits of hypotensive anesthesia in elderly patients undergoing elective
surgery.

## Key facts

- **NIH application ID:** 3120272
- **Project number:** 2R01AG008562-04
- **Recipient organization:** HOSPITAL FOR SPECIAL SURGERY
- **Principal Investigator:** Pamela G Russo
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $187,180
- **Award type:** 2
- **Project period:** 1989-07-01 → 1995-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3120272

## Citation

> US National Institutes of Health, RePORTER application 3120272, TRIAL OF HYPO TENSIVE VS. NORMOTENSIVE ANESTHESIA (2R01AG008562-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3120272. Licensed CC0.

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