# DEMENTIA, HYPONATREMIA & AGING--PEPTIDE HORMONE ROLE

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 1992 · $182,015

## Abstract

DESCRIPTION (Adapted from the applicant's abstract):  This proposal seeks
to study a clinically important disease, hyponatremia (low sodium in
blood), which can result in brain damage.  This application seeks to study
the pathogenesis of hyponatremic encephalopathy via a multidisciplinary
approach, with a goal of elucidating a mechanism by which failure of
various adaptive mechanisms can induce hyponatremic encephalopathy.  The
applicant proposes to use proton magnetic resonance imaging (MRI) of the
brain in vivo to explore possible structural changes and phosphorus (31-P)
nuclear magnetic resonance spectroscopy (MRS) to evaluate cerebral
metabolism in vivo.  Pathologic alterations will be confirmed by
histological techniques and correlated with MRI/MRS results.  Additionally,
Ca+ +, Na+, and K+ transport will be determined in vitro using synaptosomes
prepared from the brain cerebral cortex.  The effects of hormones with
established and putative effects on cerebral fluid homeostasis will also be
evaluated both in vivo and in vitro to ascertain whether specific
neuroendocrine factors are responsible for the female predilection to
hyponatremic encephalopathy.

## Key facts

- **NIH application ID:** 3120310
- **Project number:** 5R01AG008575-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **SAM.gov UEI:** KMH5K9V7S518
- **Principal Investigator:** ALLEN I ARIEFF
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $182,015
- **Award type:** 5
- **Project period:** 1991-06-01 → 1994-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3120310

## Citation

> US National Institutes of Health, RePORTER application 3120310, DEMENTIA, HYPONATREMIA & AGING--PEPTIDE HORMONE ROLE (5R01AG008575-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3120310. Licensed CC0.

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