# DEMENTIA IN SWEDISH TWINS

> **NIH NIH R01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 1992 · $317,628

## Abstract

Twin studies can be one of the most important sources of information
about the role of environmental as well as genetic factors in the
etiology of Alzheimer's disease and other dementing illnesses.  This
proposal seeks continued support for the Study of Dementia in Swedish
Twins, in order to conduct longitudinal follow-ups of all identified
cases and partners in concordant and discordant pairs, to identify
incident cases from the same population, and to obtain prospective
information from the population about exposure to environmental risks,
family history of dementia, and medical history.  An estimated 60 cases
will be followed longitudinally, with 30 to 40 incident cases anticipated
during the period encompassed by the study.  Longitudinal measures
include a cognitive battery and a Clinical Dementia ]gating.  Diagnostic
assessment of incident cases includes psychological measures, medical
evaluation, neuroimaging, and collateral interview.  Longitudinal cases
and unaffected partners will be requested to participate in an autopsy.
Various threshold or cascade models for the etiology and onset of
Alzheimer's disease seem most useful in planning analytic approaches.
Data analyses will encompass: determining concordance rates for identical
and fraternal twins, application of liability-threshold models to
estimating the relative contribution of environmental and genetic
factors, extension of case-control models using logistic regression to
encompass multiple risks, and using quantitative genetic models to
examine the distribution of phenotypes that may be indicators of dementia
in their extreme.  The Swedish sample provides a special research
opportunity to achieve these purposes.

## Key facts

- **NIH application ID:** 3120464
- **Project number:** 2R01AG008724-03
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **SAM.gov UEI:** G88KLJR3KYT5
- **Principal Investigator:** Margaret Gatz
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $317,628
- **Award type:** 2
- **Project period:** 1990-02-15 → 1997-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3120464

## Citation

> US National Institutes of Health, RePORTER application 3120464, DEMENTIA IN SWEDISH TWINS (2R01AG008724-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3120464. Licensed CC0.

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