# OPIATE RECEPTOR QUANTIFICATION IN ALZHEIMER'S DISEASE

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 1991 · $378,944

## Abstract

The primary goals of this proposal are to quantify regional mu-opiate
receptors and glucose metabolism in possible and probable Alzheimer's
Disease and normal controls by positron emission tomography (PET) and to
relate abnormalities of neuropsychological parameters in Alzheimer's
Disease to PET findings.  Additionally, we will determine the specificity
of changes in mu-opiate receptors to Alzheimer's Disease by examining Multi
Infarct Dementia patients in a similar manner.  These results will 1)
improve our understanding of the basic pathophysiology of Alzheimer's
Disease, 2) relate parameters of cognitive decline to neurochemistry and 3)
possible lead to earlier diagnosis of Alzheimer's Disease through
quantification of mu-opiate receptors than possible by clinical examination
or by measuring glucose metabolism.

## Key facts

- **NIH application ID:** 3120487
- **Project number:** 5R01AG008740-02
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **SAM.gov UEI:** FTMTDMBR29C7
- **Principal Investigator:** James JAMES FROST
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $378,944
- **Award type:** 5
- **Project period:** 1990-04-01 → 1995-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3120487

## Citation

> US National Institutes of Health, RePORTER application 3120487, OPIATE RECEPTOR QUANTIFICATION IN ALZHEIMER'S DISEASE (5R01AG008740-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3120487. Licensed CC0.

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