# DETERMINANTS OF DISABILITY IN ELDERLY MEN

> **NIH NIH R01** · UNIVERSITY OF KUOPIO · 1991 · $174,598

## Abstract

The general aim is to analyze the long-term association of
sociodemographic, behavioral and biological factors with transitions from
good to morbid or disabled health status, and eventually to death.  These
associations are studied in the Finnish, Italian and Dutch Cohorts of the
Seven Countries Study that have been followed-up with repeated
examinations during 30 years from middle-age (40-59 years) to old age
(70-89 years).  The total study population is 4755 men.
     Before the 25-year follow-up, the available data consists mainly of
cardiovascular risk factors, including diet, results of medical
examinations and mortality and morbidity follow-up.  At the 25-year
follow-up, mental and functional capacities were assessed in Finland and
Italy.  Examinations at the 30-year follow-up in all three countries
include tests of mental capacity, ADL- and IADL-activities, depressive
and other symptoms, social network, life satisfaction and objective
measures of functional capacity, in addition to the past measurements.
     The analyses will be conducted both separately for the three
countries and using pooled data.  The following four main aims correspond
also to the main responsibilities of the four countries involved in
analyzing collaborative data: 1) Prevalence and determinants of mental
and functional capacities at old age (Finland), 2) Diet and disability
(The Netherlands), 3) Risk factors and their changes - association with
mortality and morbidity (Italy), 4) Application of a multivariate
stochastic process model of human ageing and a model for multivariate
event history analysis of morbidity and dIsability change (Duke
University, USA).
     The data are collected in five sites in three countries, in very
different socio-economic and cultural settings, where common features in
ageing and health processes across sites are more likely to be a product
of basic physiological mechanisms.  Together with the long follow-up with
standardized methodology, this is one of the unique streghts of the
proposed study.

## Key facts

- **NIH application ID:** 3120521
- **Project number:** 1R01AG008762-01A1
- **Recipient organization:** UNIVERSITY OF KUOPIO
- **Principal Investigator:** MIRJA A NISSINEN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $174,598
- **Award type:** 1
- **Project period:** 1991-09-01 → 1994-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3120521

## Citation

> US National Institutes of Health, RePORTER application 3120521, DETERMINANTS OF DISABILITY IN ELDERLY MEN (1R01AG008762-01A1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3120521. Licensed CC0.

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