# LIPID PEROXIDATION IN DISEASE AND AGING

> **NIH NIH R01** · DUQUESNE UNIVERSITY · 1992 · $54,895

## Abstract

DESCRIPTION (Investigator's Abstract):  Lipid peroxidation (LP) is an
ubiquitous biochemical process involving the reaction of oxygen or
oxygen-derived radicals with polyunsaturated lipids resulting in the
generation of a variety of peroxidized lipids.  Elevated levels of certain
LP products have been associated with a variety of human diseases including
cataract formation, senile dementia and cardiac ischemia along with the
aging process.  In this study initially a normal human population
constituting various aged individuals will be studied in order to ascertain
the normal values for LP parameters and antioxidant levels.  The serum LP
parameters measured will include malondialdehyde levels determined by HPLC,
lipid hydroperoxides determined by chemiluminescence, and water-soluble
fluorescent substances.  Antioxidant levels measured will include Vitamins
A, E and C. Each of these parameters will be correlated with age to
determine if there is a trend towards an increased level of LP with age.
Since the concentration of polyunsaturated fatty acids (PUFA) in membranes
is related to the susceptibility of an organism to LP, 72 hour dietary
recall data will be collected from each participant in order to determine
the relative level of daily PUFA intake.  This is important in light of the
emphasis on increased dietary intake of PUFA as a means of reducing serum
cholesterol levels.  These individuals may have an increased susceptibility
to LP.  In the final stage of this project, plasma and dietary information
will be collected from patients with diagnosed diseases believed to be
related to LP.  Plasma will be collected and analyzed for LP parameters and
antioxidant levels as described above and compared to the normal values
previously obtained.  The results of these studies will provide a database
of the normal levels of LP products.  In addition, these studies should
provide the information required to determine if a correlation exists
between LP and age, or between LP and specific disease states.  If a
correlation can be demonstrated between LP and the aging process or
specific disease states more mechanistic cause/effect studies can be
designed in the future.

## Key facts

- **NIH application ID:** 3120851
- **Project number:** 5R01AG009033-02
- **Recipient organization:** DUQUESNE UNIVERSITY
- **SAM.gov UEI:** NGYSJ2L1LZX3
- **Principal Investigator:** David W. Seybert
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $54,895
- **Award type:** 5
- **Project period:** 1991-06-01 → 1994-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3120851

## Citation

> US National Institutes of Health, RePORTER application 3120851, LIPID PEROXIDATION IN DISEASE AND AGING (5R01AG009033-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3120851. Licensed CC0.

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