# GENE EXPRESSION IN SENESCENT CELLS

> **NIH NIH R01** · STATE UNIVERSITY OF NEW YORK AT ALBANY · 1992 · $136,737

## Abstract

The long term objective of this investigation is to investigate the
molecular basis for cellular aging and the role that gene regulation has in
that process.  These experiments will use cultured human fibroblasts
derived from normal individual and aged in vitro, from donors with
syndromes of premature senescence, and from aged donors that have been
obtained from the Human Cell Mutant Repository (maintained by the NIH-NIA).
The project focuses on the regulation of two enzymes, collagenase and
stromelysin, whose enhanced expression is correlated with in vitro
senescence.  We propose to use biochemical and molecular techniques to
analyze the regulation of those enzymes, as a function of extracellular
autocrine inducers and at the level of DNA binding proteins.  The results
of this investigation could have broad implications and provide a mechanism
through which the pleiomorphis process of aging can be regulated by a few
active factors.

## Key facts

- **NIH application ID:** 3121099
- **Project number:** 5R01AG009279-02
- **Recipient organization:** STATE UNIVERSITY OF NEW YORK AT ALBANY
- **SAM.gov UEI:** NHH3T1Z96H29
- **Principal Investigator:** Albert Millis
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $136,737
- **Award type:** 5
- **Project period:** 1991-01-15 → 1993-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3121099

## Citation

> US National Institutes of Health, RePORTER application 3121099, GENE EXPRESSION IN SENESCENT CELLS (5R01AG009279-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3121099. Licensed CC0.

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