# DIMENSIONS OF AGING--GENETIC AND EVIRONMENTAL INFLUENCE

> **NIH NIH R01** · PENNSYLVANIA STATE UNIVERSITY, THE · 1991 · $326,788

## Abstract

This proposal requests support for a continuation of a project initiated by
a Program Project grant (AG 04948). The study utilizes a systematically
derived and maintained genetically heterogeneous stock of mice in a
combined longitudinal and cross-sectional design which covers the lifespan
of the animals. Animals will be measured on a wide variety of age-related
phenotypes from a number of domains relevant to gerontology. These include
behavior, free-radicals, homeostasis, immunology, pathology and physiology.

Multivariate analyses will examine the structural relationships among
variables within and between these domains, and in changes taking place
over chronological age, and will be employed in survival analyses.

The longitudinal study involves two-generation families. Quantitative
genetic analyses based on relationships of parent and offspring, siblings,
cousins, aunt/uncle and niece/nephew will generate estimates of the genetic
and environmental contributions to the variances of the individual
phenotypes and to linear composites derived from the multivariate analyses,
and to the lifespan changes in these single and composite phenotypes.

## Key facts

- **NIH application ID:** 3121180
- **Project number:** 5R01AG009333-02
- **Recipient organization:** PENNSYLVANIA STATE UNIVERSITY, THE
- **SAM.gov UEI:** NPM2J7MSCF61
- **Principal Investigator:** GERALD E MCCLEARN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $326,788
- **Award type:** 5
- **Project period:** 1990-08-01 → 1992-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3121180

## Citation

> US National Institutes of Health, RePORTER application 3121180, DIMENSIONS OF AGING--GENETIC AND EVIRONMENTAL INFLUENCE (5R01AG009333-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3121180. Licensed CC0.

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