# EPIDEMIOLOGY OF AGING AND PHYSICAL PERFORMANCE

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 1992 · $450,000

## Abstract

This proposal is for a 5-year study to examine the hypothesis that lowered
levels of objectively measured exercise capacity and pulmonary function are
important predictors of reduced age-related levels of physical performance
after adjustment for lifestyle (e.g., exercise habits), disease morbidity
and smoking.  The study also will assess the effects of aging itself on
changes in exercise capacity and lung function after adjustment for
important covariates.  Finally, the study will assess the extent to which
social variables (e.g., living arrangements) affect the association between
age, exercise and lung function on levels of physical performance
(particularly ADL and IADL).

A community-based sample of approximately 3673 non-institutionalized male
and female residents of Sonoma, CA aged greater than or equal to 55 years
will be enrolled.  Baseline home interviews and laboratory-based
assessments will be conducted.  The home interview will address self-
reported and direct measures of physical performance, disease morbidity,
current and past exercise habits, history of smoking and alcohol
consumption, level of cognitive function, symptoms of depression, living
arrangements and other measures of social networks and social support.
Exercise capacity (time on treadmill, O2 consumption and other
physiological variables measured during treadmill exercise) and pulmonary
function (maximum expiratory flow-volume curves, inspiratory and expiratory
pressures) will be measured in a community-based laboratory.  Two
subsequent contacts will be made with the respondents.  Approximately 16
months after baseline, a second home interview will be conducted.  A third
contact will be made 16 months later to administer the home interview and
to conduct a second laboratory evaluation.

In addition to the determination of the extent to which baseline exercise
capacity and lung function predict subsequent levels of physical
performance, this study will provide data essential for the development of
studies to test strategies to improve the health and adaptive capacities of
the elderly.

## Key facts

- **NIH application ID:** 3121232
- **Project number:** 1R01AG009389-01A2
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **SAM.gov UEI:** KMH5K9V7S518
- **Principal Investigator:** Ira B Tager
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $450,000
- **Award type:** 1
- **Project period:** 1992-09-24 → 1993-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3121232

## Citation

> US National Institutes of Health, RePORTER application 3121232, EPIDEMIOLOGY OF AGING AND PHYSICAL PERFORMANCE (1R01AG009389-01A2). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3121232. Licensed CC0.

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