# EPIDEMIOLOGY OF ANTI-HYPERTENSIVE DRUGS IN THE ELDERLY

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 1993 · $152,305

## Abstract

The purpose of this project is to determine whether the use of various
types of anti-hypertensive agents in the elderly is associated with
differences in side effects, risk factors, and the incidence of clinical
and subclinical cardiovascular-disease (CVD) endpoints.  The setting for
this project is the Cardiovascular Health Study, a prospective cohort
study of risk factors for stroke and coronary heart disease in persons
65 and older.  In June 1990, 5201 participants completed an examination
that included:  questionnaires about medication use, diet, cognitive
function, depression, physical function and activity; fasting and 2-hr
post challenge glucose and insulin; fasting total cholesterol, HDL
cholesterol, fibrinogen and others; seated, orthostatic and ankle-arm
blood pressures; anthropometric measures; electrocardiography, Holter
monitoring, echocardiography, and carotid ultrasonography.  Follow-up
procedures have included semi-annual contacts and surveillance for CVD
endpoints.  Cohort retention has exceeded 96% of survivors.  The second
examination began in June 1992, repeats the baseline measures, adds MRI
head scans, and recruits 600 new minority participants.  We developed new
methods to assess medication use; for estimating use of beta-blockers and
beta-agonists, this method, but not self-report, showed a significant
effect on mean heart rate.  Proposed validation efforts will use blood
levels of selected medications.  Complete data on medications were
available for over 98% of the cohort at each annual visit; analyses of
the year-one follow-up data suggest that the use of anti-hypertensive
medications was stable within individuals.  Using Cox proportional-
hazards model and new models for longitudinal data analysis, we will
assess the association between the use of various types of
antihypertensive medications and side effect, CVD risk factors,
intermediate outcomes, and major CVD endpoints.  Key intermediate
outcomes include changes in left ventricular mass, carotic
atherosclerosis, ECG abnormalities, and MRI-scan results.  This project
will enable us to pursue vigorously a set of related analyses of the
effects of anti-hypertensive medicines on a variety of outcomes in the
elderly.

## Key facts

- **NIH application ID:** 3121425
- **Project number:** 1R01AG009556-01A2
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **SAM.gov UEI:** HD1WMN6945W6
- **Principal Investigator:** Bruce M Psaty
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $152,305
- **Award type:** 1
- **Project period:** 1993-09-01 → 1995-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3121425

## Citation

> US National Institutes of Health, RePORTER application 3121425, EPIDEMIOLOGY OF ANTI-HYPERTENSIVE DRUGS IN THE ELDERLY (1R01AG009556-01A2). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3121425. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*