# REDUCTION IN ADRS VIA COMPUTERIZED PHARMACY INTERVENTION

> **NIH NIH R01** · WASHINGTON STATE UNIVERSITY · 1991 · $203,830

## Abstract

The elderly often suffer from multiple diseases which require the use of
multiple medications often resulting in adverse drug reactions (ADRs).
While currently making up 17 percent of the U.S. population, people over
60 years of age account for newly 40 percent of the drug-related
hospitalizations and more than half the deaths from ADRS. Most ADRs are
extensions of known pharmacological effects and are preventable. The goal
of this study is to reduce the rate of ADRs in institutionalized elderly
patients by melding an existing computer data base with therapeutic
risk-management methodology to develop and implement intervention
strategies. The existing network is a pharmacy-based computerized system
developed by the Spokane Area Society of Hospital Pharmacists designed to
track ADRS. This goal will be accomplished in three steps: 1) The ten most
common drug responsible for ADRs in hospitalized elderly patients will be
identified as well as the risk factors a&%&ted with ADRs within each of
these ten drugs; 2) A hospital pharmacy-based, computerized intervention
system that will quickly identify elderly patients at high risk for an ADR
from any of the targeted drugs. and recommended preventive strategies for
the prescribing physician will be developed and implemented; 3) The impact
of this intervention system will be evaluated using a controlled
randomized study design. Ibis system will be designed and implemented
within the six major hospitals in Spokane, Washington. Patients 60+ years
of age, taking one or more of the targeted drugs and having at least one
of the identified ADR high risk factors, and hospitalized at one of the
six hospitals between January 1, 1992 and December 31, 1993 will be
randomly assigned to the intervention group or a control group. The
control group will receive usual and customary hospital care. Data will be
analyzed to assess the rate of ADRS, cost effectiveness of the system, and
average length of stay in an intervention group compared to the control
group. After completion of the project, the intervention system and
software will be transportable and its use in other institutions and
environments will be encouraged.

## Key facts

- **NIH application ID:** 3121445
- **Project number:** 1R01AG009568-01
- **Recipient organization:** WASHINGTON STATE UNIVERSITY
- **SAM.gov UEI:** XRJSGX384TD6
- **Principal Investigator:** MARTIN J JINKS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $203,830
- **Award type:** 1
- **Project period:** 1991-02-01 → 1995-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3121445

## Citation

> US National Institutes of Health, RePORTER application 3121445, REDUCTION IN ADRS VIA COMPUTERIZED PHARMACY INTERVENTION (1R01AG009568-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3121445. Licensed CC0.

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