# EPIDEMIOLOGIC STUDY OF PERSONS WITH ALZHEIMER'S DISEASE

> **NIH NIH R01** · RUSH UNIVERSITY MEDICAL CENTER · 1993 · $219,871

## Abstract

DESCRIPTION:  (Adapted from Applicant's Abstract) A longitudinal study of a
cohort of 350 community-dwelling persons with clinically diagnosed
Alzheimer's disease followed for an average period of four years is
proposed.  The descriptive aims of the study will be to characterize change
in cognitive function using sequential, annual neuropsychological
performance tests and to describe quantitatively, in this cohort, entry
into institutional long-term care, hospitalization, and the occurrence of
behavioral abnormalities and impaired physical function.

The study will test two sets of hypotheses.  The first is, that among those
with Alzheimer's disease, the presence of each of the following factors
predicts greater decline in cognitive function:  lower level of formal
education, lower occupational prestige, occupation with a lower educational
development category and lower family income.  The second is that entry
into institutional long-term care and hospitalization are more strongly
predicted by the presence of behavioral abnormalities and by the presence
of physical impairment than by level of cognitive impairment.  Because
behavioral abnormalities and impairment of physical function may be more
susceptible to intervention than the underlying cognitive deficit itself,
study results have the potential to serve as a basis for design of trials
that may lead to reduction in disease morbidity and cost.

## Key facts

- **NIH application ID:** 3121917
- **Project number:** 5R01AG009966-03
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **SAM.gov UEI:** C155UU2TXCP3
- **Principal Investigator:** DENIS A EVANS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $219,871
- **Award type:** 5
- **Project period:** 1991-09-01 → 1996-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3121917

## Citation

> US National Institutes of Health, RePORTER application 3121917, EPIDEMIOLOGIC STUDY OF PERSONS WITH ALZHEIMER'S DISEASE (5R01AG009966-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3121917. Licensed CC0.

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