# AGE-RELATED ERP MEASURES IN ALZHEIMER'S DISEASE

> **NIH NIH R01** · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · 1992 · $167,497

## Abstract

Event-related brain potentials (ERPs) and performance measures will be
recorded from patients with probable Alzheimer's disease (PAD), and age-
matched normal controls.  The main thrust of the proposal is to assess
performance on explicit and implicit tests of memory in carefully
controlled designs, in an attempt to uncover the physiological
underpinnings of memory deficiencies in PAD reported in the behavioral
literature.  Three experiments are proposed:  1) the first asks the
question how do PAD subjects differ from age-matched controls (behaviorally
and with respect to ERPs) in the ways in which they process pictorial and
lexical input on-line, and the ways in which they remember and retrieve
such input during implicit (fragment completion) and explicit (recognition)
testing; 2) the second is aimed at assessing the adequacy of encoding
operations at study.  Orienting task will be used to manipulate encoding
activity.  ERP activity at study will be computed, separately by orienting
task, as a function of subsequent stem completion (implicit) and cued
recall (explicit) performance.  This activity (i.e., the ERP "memory
effect") is expected to differ between the groups as a function of
differences in encoding operations; 3) the third seeks to determine if the
ERP and behavioral repetition effect will be modulated by the number of
repetitions of an item (i.e., its "memory strength") similarly in PAD and
age-matched control subjects.  In constrast to the previous experiment,
memory will only be tested implicitly, and the focus is on retention.  In
general, it is also expected that the amplitude of the ERP old/new
repetition effect will reflect the magnitude of priming during on-line and
delayed memory tasks.  ERPs will be recorded from several scalp placements
in order to determine whether scalp distributions and, by implication,
their intracranial generators, differ systematically between the groups.
The data will be relevant to age-related pathological changes in memory
function, and their physiological underpinnings.

## Key facts

- **NIH application ID:** 3121935
- **Project number:** 5R01AG009988-02
- **Recipient organization:** NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- **SAM.gov UEI:** TYVNMW8FNQQ3
- **Principal Investigator:** DAVID FRIEDMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $167,497
- **Award type:** 5
- **Project period:** 1991-08-15 → 1994-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3121935

## Citation

> US National Institutes of Health, RePORTER application 3121935, AGE-RELATED ERP MEASURES IN ALZHEIMER'S DISEASE (5R01AG009988-02). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3121935. Licensed CC0.

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