# GROWTH REGULATION IN NORMAL AND TRANSFORMED CELLS

> **NIH NIH R01** · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · 1991 · $203,168

## Abstract

Cell proliferation in higher eukaryotes is a tightly regulated
process that is largely governed by extracellular factors.  These
include hormones, growth factors, growth inhibitors and the
cellular microenvironment, for example, the proximity of
neighboring cells.  Tumorigenic cells exhibit faulty or unregulated
growth control, and they often fail to heed one or more of the
environmental signals that limit the proliferation of normal cells.

There is substantial evidence that growth-controlling environment
signals have acute effects upon the expression of specific genes
that are though important for the proliferative response.  This
proposal examines the biochemical mechanisms by which
environmental signals alter the expression of certain genes in
nontumorigenic murine fibroblasts, in tumorigenic derivatives
derived by chemical or viral transformation, and in transfected
derivatives bearing one or more known genetic change.  The
experiments will determine the intracellular pathways by which
some environmental factors induce or suppress the transcription,
mRNA accumulation or translation of certain growth-related
genes, the role of certain protein kinases and other regulatory
proteins in mediating changes in gene expression and the
proliferative response, and  they will explore the function of some
of the genes in regulating proliferation.

These studies will provide an important biochemical and
molecular biological base for understanding the interactions
between environmental signals and specific gene expression in the
regulation of normal and tumor cell growth.

## Key facts

- **NIH application ID:** 3121962
- **Project number:** 9R01AG010004-04
- **Recipient organization:** UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
- **SAM.gov UEI:** ENBLDJUN4N73
- **Principal Investigator:** Judith Campisi
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $203,168
- **Award type:** 9
- **Project period:** 1987-09-01 → 1996-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3121962

## Citation

> US National Institutes of Health, RePORTER application 3121962, GROWTH REGULATION IN NORMAL AND TRANSFORMED CELLS (9R01AG010004-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3121962. Licensed CC0.

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