# DEMENTIA IN THE BLACK AGED--AD AND MID

> **NIH NIH R01** · RUSH UNIVERSITY MEDICAL CENTER · 1993 · $346,361

## Abstract

DESCRIPTION:  (Adapted from Applicant's Abstract) Alzheimer's disease (AD)
and multi-infarct dementia (MID) are the two leading causes of progressive
and irreversible dementia.  Identifying risk factors associated with AD and
MID is an important step in the search for etiology as well as intervention
and prevention strategies.  The major objective of this research
application is to identify and clarify risk factors for AD and MID in an
urban black aged population.  Blacks have been underrepresented in
biomedical, behavioral and psychosocial studies of dementia.  The
investigators propose to study epidemiological, medical, neuropsychological
and neuroradiological characteristics by carrying out a case-control study
in two groups of index cases, blacks with AD and blacks with MID, and a
control group composed of blacks with multiple cerebral infarcts but
without cognitive impairment.

The second major objective of this project is to follow the case-control
populations longitudinally to determine the rate of decline in cognitive
status, to determine and compare outcome variables measuring cognitive and
functional status, and mortality among black AD and MID cases with respect
to descriptive history of these variables over time, and to develop
hypotheses about medical and psychosocial factors that contribute to the
survival disadvantage of aging black Americans.

A third major objective is to accumulate enough standardized
neuropathological observations on deceased cases using neuropathological
criteria developed by CERAD to validate clinical diagnoses of AD and
clarify valid criteria for MID in blacks.  The investigators are proposing
a case-control study to gather empirical data on risk factors as a prelude
to the design of targeted intervention studies.

## Key facts

- **NIH application ID:** 3122059
- **Project number:** 5R01AG010102-03
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **SAM.gov UEI:** C155UU2TXCP3
- **Principal Investigator:** PHILIP B GORELICK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $346,361
- **Award type:** 5
- **Project period:** 1991-09-01 → 1996-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3122059

## Citation

> US National Institutes of Health, RePORTER application 3122059, DEMENTIA IN THE BLACK AGED--AD AND MID (5R01AG010102-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3122059. Licensed CC0.

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