# MODULATING URINARY TRACT INFECTION IN ELDERLY FEMALES

> **NIH NIH R01** · TULANE UNIVERSITY OF LOUISIANA · 1993 · $180,986

## Abstract

This study will evaluate nonhuman primates with surgical as opposed to
natural menopause to determine whether hormonal factors affect the immune
response or whether the defective immune response of the elderly is due
to some other factor.  This will be done by, in one case,, bilateral
oophorectomy, studying animals with or without replacement hormones.  The
group of animals with normal menstrual cycles and those given hormonal
replacement will be challenged with two strains of E. coli, one a
nephropathogenic P-fimbriated form and the other a type 1 fimbriated
non-pathogenic organism.  The course of the bladder infections in the
normal animals, those with surgical menopause and those with replacement
hormone therapy will be evaluated and the immune system will also be
evaluated prior to and after bladder infections.  These animals should
determine whether a lack of hormones itself affects the immune response .
If so, the type of replacement therapy to reverse this change will have
been demonstrated.  Studies in elderly postmenopausal monkeys then will
be done to determine whether the ideal hormonal replacement reverses the
immune defects of the elderly.  The knowledge thus gained may have a
direct effect on the very high incidence of urinary tract infection in
elderly females if it is shown that hormonal replacement therapy is
beneficial.

## Key facts

- **NIH application ID:** 3122269
- **Project number:** 1R01AG010292-01A1
- **Recipient organization:** TULANE UNIVERSITY OF LOUISIANA
- **SAM.gov UEI:** XNY5ULPU8EN6
- **Principal Investigator:** JAMES A. ROBERTS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $180,986
- **Award type:** 1
- **Project period:** 1993-03-01 → 1996-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3122269

## Citation

> US National Institutes of Health, RePORTER application 3122269, MODULATING URINARY TRACT INFECTION IN ELDERLY FEMALES (1R01AG010292-01A1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3122269. Licensed CC0.

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