# ALZHEIMER'S DISEASE AND DEMENTIA IN CHINA

> **NIH NIH R01** · SAN DIEGO STATE UNIVERSITY · 1991 · $178,515

## Abstract

Funding is requested in this proposal to support interrelated studies on
Alzheimer's disease and dementia in the People's Republic of China, using
a complex, multi-phasic, and historically unprecedented epidemiologic
dataset, collected in Shanghai over a period of two years (1987-88) by a
multi-disciplinary team of investigators including the P.I.  As of this
writing, at least seven papers have been published from this dataset in
refereed scientific journals.  This is the first time that funding is being
requested to do further data analyses on various aspects of the dataset
that have not yet been analyzed nor published.  In response to NIA's
ongoing program announcement, this team of investigators propose to conduct
several studies under the following broad topics:  (1) the epidemiology of,
and the identification of risk factors for, dementia and Alzheimer's
disease in Chinese context; (2) the evaluation of the specificity,
sensitivity, reliability and validity of diverse screening and diagnostic
assessment procedures and instruments used in our study; and (3) the
characterization of the sampling procedure used in the Shanghai
epidemiologic survey and determination of its cost-effectiveness vis-a-vis
other traditional approaches.  Although several studies are proposed here,
they share only one single overriding research objective:  What is the
epidemiology of Alzheimer's disease and related dementias in later life in
the People's Republic of China--using Shanghai as a data collection point?
To answer this question, the investigators are sensitive to a host of
issues concerning the effect of sample design on the estimation of rates,
and the sensitivity, specificity, validity, reliability and cross-cultural
applicability of instruments used to determine caseness in a society where
the language and culture is drastically different from the West where these
instruments were originally developed.  This research problem has broad
implications for basic research into the etiology of Alzheimer's disease
and related dementias, as well as practical clinical use.

The requested funding is intended for use in the following ways:   (1) to
release the time of these researchers and advanced students from competing
demands for teaching, administration, and clincal work; and (2) to produce
a critical mass of substantive findings from the present study in order to
provide other researchers in the area of aging a useful knowledge base from
which to develop future investigations.  The first 12-month budget
requested is 258,666.  The total budget requested over three years is
$818,349.

## Key facts

- **NIH application ID:** 3122292
- **Project number:** 1R01AG010327-01
- **Recipient organization:** SAN DIEGO STATE UNIVERSITY
- **SAM.gov UEI:** H59JKGFZKHL7
- **Principal Investigator:** ELENA S. YU
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $178,515
- **Award type:** 1
- **Project period:** 1991-06-01 → 1993-05-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3122292

## Citation

> US National Institutes of Health, RePORTER application 3122292, ALZHEIMER'S DISEASE AND DEMENTIA IN CHINA (1R01AG010327-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3122292. Licensed CC0.

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