# PROXIMAL FEMUR ARCHITECTURE IN OLDER WOMEN

> **NIH NIH R01** · HENRY FORD HEALTH SYSTEM · 1991 · $82,100

## Abstract

As a companion project to Dr. Kleerekoper's clinical prevention study of
hip fracture and estrogen replacement therapy (ERT) (RFA AG91-04), this
application seeks support to collect and analyze data which describes the
internal bone architecture and overall geometry of the proximal femur.  A
Computed Tomography (CT) technique will be used which produces a fine
three-dimensional (3D) array of bone density values, unaffected by the
absolute or relative orientation of the subject Baseline and annual studies
will be obtained on all 210 subjects recruited.  Sophisticated algorithms
which realign the 3D data obtained serially provides very consistent
architecture measures.  Regional density values will be determined for
specific volumes of both cancellous and cortical bone tissue.

These specific questions will be directly addressed by this project in
combination with a related research grant (R29-AG08776-02):

1. Is there a typical pattern of regional bone mineral density in the
proximal femur for older (skeletally healthy) women?  How do the
architectural parameters measured by the 3D-CT technique relate to the 2D-
DXA (dual-energy x-ray absorptiometry) results?

2. What is the typical change over time of this density pattern?  Do
elements of structural geometry affect bone loss patterns and/or rates?
How do rates of cortical and cancellous bone loss differ?

3. Is this typical bone loss pattern altered by the proposed clinical
intervention (ERT)?

4. Are the density patterns observed in this group different from those of
a population who have sustained a Type II Osteoporotic hip fracture?  Can
a vulnerable proximal femur architecture be recognized early, thus allowing
the discrimination of those patients at the highest risk of fracture to be
clinically treated?

5. Do the bone loss patterns appear to be changing the bone density
distribution toward the Typica Osteoporosis group architecture?  Are there
varying rates of bone loss across the postmenopausal population in the
proximal femur?  Can a subgroup of women with high bone loss rates be
identified to further focus our treatment to those most likely to benefit?

## Key facts

- **NIH application ID:** 3122303
- **Project number:** 1R01AG010374-01
- **Recipient organization:** HENRY FORD HEALTH SYSTEM
- **SAM.gov UEI:** R9NXPE2GTCN9
- **Principal Investigator:** DIANNA D CODY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $82,100
- **Award type:** 1
- **Project period:** 1991-09-30 → 1996-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3122303

## Citation

> US National Institutes of Health, RePORTER application 3122303, PROXIMAL FEMUR ARCHITECTURE IN OLDER WOMEN (1R01AG010374-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3122303. Licensed CC0.

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