# AGGRESSIVE BEHAVIOR IN PERSONS WITH ALZHEIMER'S DISEASE

> **NIH NIH R01** · RUSH UNIVERSITY MEDICAL CENTER · 1991 · $113,788

## Abstract

Physical aggression and other indices of irritable affect have been
consistently identified as potential risk factors for institutionalization
and other negative care-related outcomes in patients with Alzheimer's
disease and related conditions.  A cohort of 255 persons with the clinical
diagnosis of Alzheimer's disease, stratified on initial dementia severity
level, will be prospectively studied over 12 months with a weekly
surveillance protocol to capture specific episodes of physical aggression
and situational factors.

The descriptive aims of this study will be to characterize the number of
persons with aggressive episodes and the rate of these episodes over 12
months as a function of initial level of cognitive impairment.  In
addition, the study will quantitatively describe six situational factors
related to aggressive episodes.

The study will test the hypotheses that, among patients with Alzheimer's
disease, the presence of each of these factors predicts episodes of
aggression:  severe cognitive impairment, premorbid episodes of aggression,
and severity of other behavioral disturbances.  In addition, the data will
permit testing the hypothesis that the presence and frequency of aggressive
episodes predicts increased levels of emotional distress in the primary
caregiver.

## Key facts

- **NIH application ID:** 3122574
- **Project number:** 1R01AG010647-01
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **SAM.gov UEI:** C155UU2TXCP3
- **Principal Investigator:** DAVID W GILLEY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $113,788
- **Award type:** 1
- **Project period:** 1991-09-30 → 1994-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3122574

## Citation

> US National Institutes of Health, RePORTER application 3122574, AGGRESSIVE BEHAVIOR IN PERSONS WITH ALZHEIMER'S DISEASE (1R01AG010647-01). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3122574. Licensed CC0.

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