# AGING AND DEMENTIA--REDUCING DISABILITY IN ALZHEIMER'S

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 1993 · $394,581

## Abstract

Although the prevalence of dementia increases with advancing age, and the
disability, which accompanies dementia is far-reaching, few effective
treatment programs exist. Capitalizing on our knowledge of physical
frailty in older adults, behavioral and affective disturbance in AD, and
the impact of these problems on caregivers' affective health, this project
is designed to develop, implement, and evaluate an integrated model of
medical, behavioral, and psychosocial intervention. Treatment is designed
to reduce the physical, behavioral, and affective problems in patients
with AD and to alleviate the depression and burden in their caregivers.
Two hundred community residing AD patient-caregiver pairs will be randomly
assigned to the active treatment or to treatment-as-usual (acute medical
care, advice and support, and crisis intervention). The active
intervention is designed to simulate clinical practice by providing a
step-up approach to care for all AD patients and their caregivers. The
specific goals of intervention are to reduce physical disability by
improving patient mobility, maintaining adequate nutrition, decreasing
adverse drug reactions, and decreasing falls and fractures; to reduce
affective disability by identifying and treating depressive symptoms in
patients and caregivers; to decrease patient behavior problems; and to
decrease caregiver burden. All subjects are members of a community-based
HMO and are enrolled in an ongoing Alzheimer's Disease Patient Registry
that identifies and follows incident cases of AD. Subjects will be
assessed upon enrollment in the investigation, and at six month intervals
for a period of at least two years to evaluate their cognitive, physical,
behavioral, and affective status. Health care utilization and costs will
also be evaluated. It is hypothesized that AD patients in the active
intervention will show significantly better outcome than controls, as
deflected in better health, fitness, and mobility, less depression, and
fewer behavior problems over the two year period. Further, it is
hypothesized that caregivers in the active treatment will be less
depressed and burdened than caregivers in the control condition. Finally,
reduced health care utilization is expected in the active treatment group
compared with the control group.

## Key facts

- **NIH application ID:** 3122814
- **Project number:** 1R01AG010845-01A1
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **SAM.gov UEI:** HD1WMN6945W6
- **Principal Investigator:** LINDA TERI
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $394,581
- **Award type:** 1
- **Project period:** 1993-09-30 → 1998-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3122814

## Citation

> US National Institutes of Health, RePORTER application 3122814, AGING AND DEMENTIA--REDUCING DISABILITY IN ALZHEIMER'S (1R01AG010845-01A1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3122814. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*