# AGE & EXERCISE--MUSCLE FUNCTION BY NMR AND PERFORMANCE

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 1992 · $217,717

## Abstract

Our goal is to relate morphological and in vivo functional properties of
elderly muscle to the performance in activities of daily living before and
after strength or endurance training.  We employ a new technique for
examining in vivo muscle energetics, the Quantitative Energetics Stress
Test (QUEST), and a new method for direct observation of performance in
daily activities, the Physical Functional Performance (PAP) profile.  With
nuclear magnetic resonance (31P NMR) spectroscopy of limb muscle (vastus
lateralis) under maximal stimulation conditions, we will use creatine
phosphate (PCr) changes to measure both ATp breakdown and recovery.  Muscle
energetics will be evaluated as they relate to the myosin isoform
composition (assessing PCr breakdown) and capillary and mitochondria
densities (assessing PCr recovery) from muscle biopsies of the vastus
lateralis.  These new techniques will be combined with established methods.
Muscle strength will be characterized by isokinetic tests of maximal force
production (peak torque), and with NMR imaging to determine muscle
cross-sectional area.  Physical Functional Performance will be evaluated by
direct observation of performance in daily living tasks (PAP), of gait and
balance, and of reaction time.  Muscle properties will be correlated with
functional performance measures.  In pre-trained elderly subjects, we first
establish the relationships between in vivo muscle function the
morphological and biochemical properties of elderly muscle.  Second, we
examine how performance (e.g., stair-climbing) depends on these in vivo
muscle functional properties (e.g., muscle strength).  On the basis of
these baseline relationships, we will evaluate how performance and the
underlying in vivo properties of the muscle in elderly subjects are
uniquely altered by specific exercise training.

## Key facts

- **NIH application ID:** 3122824
- **Project number:** 1R01AG010853-01
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **SAM.gov UEI:** HD1WMN6945W6
- **Principal Investigator:** KEVIN E CONLEY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $217,717
- **Award type:** 1
- **Project period:** 1992-09-11 → 1997-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3122824

## Citation

> US National Institutes of Health, RePORTER application 3122824, AGE & EXERCISE--MUSCLE FUNCTION BY NMR AND PERFORMANCE (1R01AG010853-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3122824. Licensed CC0.

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