# 1H AND 31P MRSI OF AGING BRAIN AND SENILE DEMENTIA

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 1993 · $356,204

## Abstract

The goal of this project is to determine the metabolic
disturbances within tissue produced by disease and therapy.  High-
energy phosphates, pH, lactate, and other metabolites will be
measured in surface tumors, heart, and kidneys of human patients,
using 31P and 1H NHR.  Both Bo and B1 localization techniques
will be developed, simulated, tested on phantoms, normal
subjects, and patients.  Cancer studies will examine the possibility
that metabolic changes are a sensitive and early index of the
response to therapy.  These studies will begin with large
superficial squamous cell carcinomas of the head and neck.  After
completing a survey to characterize metabolic composition,
heterogeneity, and variability, pilot experiments will determine
the effects and time course of chemo- and radiation therapy.  A
prospective trial will correlate the spectral changes with the
ultimate response to therapy, determined by MRI, CT, and
ultimate outcome.  Heart studies are designed to test the
hypothesis that disorders of cardiac energy metabolism may be
responsible for functional abnormalities in cardiac disease.  31P
and 1H NMR studies of coronary ischemia in the pig will be
continued using surgically implanted coils.  Spectral localization
techniques will be developed using the pig and human subjects.
The effects of exercise and pacing will be determined and the
metabolic alterations produced by myocardiopathy, hypertrophy,
transplant rejection, and ischemia will be examined.  Human
kidney studies are aimed at investigating the metabolic changes
produced by acute tubular necrosis.  Once localization techniques
are developed, and the normal kidney is examined, the changes
associated with acute tubular necrosis will be characterized.
Renal function will be correlated with NMR results to determine
if spectral changes predict the outcome, or the response to
therapy in a series of patients with ATN.

## Key facts

- **NIH application ID:** 3122874
- **Project number:** 5R01AG010897-10
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **SAM.gov UEI:** KMH5K9V7S518
- **Principal Investigator:** MICHAEL W WEINER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $356,204
- **Award type:** 5
- **Project period:** 1992-07-01 → 1996-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3122874

## Citation

> US National Institutes of Health, RePORTER application 3122874, 1H AND 31P MRSI OF AGING BRAIN AND SENILE DEMENTIA (5R01AG010897-10). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3122874. Licensed CC0.

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