# RISK FACTORS FOR INCIDENT AD IN A BIRACIAL COMMUNITY

> **NIH NIH R01** · RUSH UNIVERSITY MEDICAL CENTER · 1993 · $1,282,493

## Abstract

A study of incident, clinically-diagnosed Alzheimer's disease is proposed
in a biracial population of 9,800 persons 65 years of age and older
living in a geographically defined area of Chicago.  The study will test
the following major hypotheses: (a) Incidence of clinically diagnosed
Alzheimer's disease is higher among African Americans than among white
Americans. (b) Incidence of clinically diagnosed Alzheimer's disease is
higher among persons with lower educational attainment. (c) Incidence of
clinically diagnosed Alzheimer's disease is lower among persons who smoke
cigarettes than among comparable non-smokers. (d) Incidence of clinically
diagnosed Alzheimer's disease is higher among women than men.  In
addition, the study will provide estimates of the age-specific incidence
of clinically diagnosed Alzheimer's disease in this community, identify
predictors of change in cognitive function over a three-year period in
the population and, as a secondary goal, provide estimates of the
age-specific prevalence of Alzheimer's disease.

The study will have two major operational components, separated by three
years; each component will have two similar stages.  The first stage will
be a population interview that contains brief performance tests of
cognitive function.  The second stage will be clinical evaluation for
Alzheimer's disease of a random sample of participants, stratified by
age, sex, race and first stage cognitive test performance.  Persons with
Alzheimer's disease may be identified from any stratum not merely from
the poor performance group.  The design permits risk factor information
to be measured prior to the onset of overt disease.  Standard diagnostic
criteria will be used, evaluators will be blinded to sampling category
and structured questionnaires and evaluation techniques will be used.

## Key facts

- **NIH application ID:** 3123091
- **Project number:** 1R01AG011101-01
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **SAM.gov UEI:** C155UU2TXCP3
- **Principal Investigator:** DENIS A EVANS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $1,282,493
- **Award type:** 1
- **Project period:** 1993-03-01 → 1998-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3123091

## Citation

> US National Institutes of Health, RePORTER application 3123091, RISK FACTORS FOR INCIDENT AD IN A BIRACIAL COMMUNITY (1R01AG011101-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3123091. Licensed CC0.

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