# TRANSMENOPAUSAL CHANGES IN SEX HORMONES AND LIPIDS

> **NIH NIH R01** · NEW ENGLAND RESEARCH INSTITUTES, INC. · 1993 · $165,191

## Abstract

This four-year continuation proposes to add three data points, 9-10
months apart (T4-T6, to the four already completed (T0-T3), in order to
complete a unique prospective study of a cohort of 427 pre-and peri-
menopausal women aged 50-60 years (80% were aged 50-55 years) in 1986
when data collection began.

The primary research questions for the proposed continuation are: 1) How
do decreases in endogenous hormones affect levels in total cholesterol
and lipid fractions in normal women undergoing a natural menopause; 2)
How do transmenopausal changes in sex hormones interact with other
cardiovascular risk factors (blood pressure, body mass, diet components,
smoking); and 3) Are there pre-disposing, pre-menopausal or menopausal
factors which increase post-menopausal CVD risk independently of
estrogen changes (for example, timing of menopause, length of peri-
menopause)?

To address these questions, prospective data are being collected on:
FSH, LH, Estradiol, Estrone, SHBG, DHEA-S, Total Cholesterol, HDL-C,
HDL-1, HDL-2, Apo-A1, Apo-B, Serum Glucose, Blood Pressure, BMI, current
drug use, cigarette smoking, alcohol consumption, diet, sexual function,
and other pertinent health and lifestyle information.

The unique features of this study include: sufficient numbers and
follow-up period to reliably estimate transmenopausal changes in
hormones and lipids and their association; cohort of women which
represents U.S. women in the age group 50-60 and which has known
representation of Massachusetts women from which it was sampled;
information on key covariates (smoking, BMI) with which to adequately
adjust estimates and associations: and the expertise to fully analyze
these longitudinal data using the latest random effects modelling
approaches.

## Key facts

- **NIH application ID:** 3123380
- **Project number:** 5R01AG011431-02
- **Recipient organization:** NEW ENGLAND RESEARCH INSTITUTES, INC.
- **SAM.gov UEI:** FFWJTXCKDLK5
- **Principal Investigator:** SONJA M MCKINLAY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $165,191
- **Award type:** 5
- **Project period:** 1992-09-30 → 1996-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3123380

## Citation

> US National Institutes of Health, RePORTER application 3123380, TRANSMENOPAUSAL CHANGES IN SEX HORMONES AND LIPIDS (5R01AG011431-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3123380. Licensed CC0.

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