# RISK FACTORS FOR TRANSMENOPAUSAL BONE LOSS

> **NIH NIH R01** · NEW ENGLAND RESEARCH INSTITUTES, INC. · 1992 · $225,652

## Abstract

This four-year continuation proposes to add three data points, 9-10
months apart (T4-T6) to the four already collected (T0-T3), in order to
complete eight years of follow-up including seven data points (bone
density of two forearm sites) and six data points (spine bone density) on
subjects in a cohort of 427 pre- and perimenopausal women born 1926-1936,
of known representation of an original, community sampled cohort.

The primary research questions for the proposed continuation are: 1) What
are the normal rates of bone loss in an eight-year period, from pre- to
postmenopause in the three sites and what are the independent effects of
bone type (cortical vs. trabecular) and weight bearing? 2) How are
transmenopausal endogenous hormone changes related to transmenopausal
bone loss? and 3) Are there potential risk factors which affect the rate
of bone loss and predict one or more subgroups of 'rapid' bone losers?

To address these questions, prospective data are being collected for: the
3 bone sites; the following sex steroid hormones: Estrone, Estradiol,
FSH, LH, SHBG, and DHEA-S: BMI, current drug use, exercise, diet, smoking
and alcohol use.  With the proposed data points, this prospective study
will have sufficient follow-up to reliably estimate the normal rate of
bone loss at menopause, as well as the factors likely to affect it.

Major strengths of the study include; adequacy of numbers of subjects and
follow-up; reliable measurement of bone density at 3 sites allowing
independent comparisons of the effect of bone structure and weight
bearing on bone loss; measurement of a wide range of potential risk
factors for bone loss; known representation of the cohort; and
application of the latest statistical techniques to complex longitudinal
data.

## Key facts

- **NIH application ID:** 3123381
- **Project number:** 1R01AG011432-01
- **Recipient organization:** NEW ENGLAND RESEARCH INSTITUTES, INC.
- **SAM.gov UEI:** FFWJTXCKDLK5
- **Principal Investigator:** ALAN Maurice JETTE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $225,652
- **Award type:** 1
- **Project period:** 1992-09-30 → 1996-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3123381

## Citation

> US National Institutes of Health, RePORTER application 3123381, RISK FACTORS FOR TRANSMENOPAUSAL BONE LOSS (1R01AG011432-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3123381. Licensed CC0.

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