# MECHANISMS OF AGING--ENHANCED HEART ADENOSINE

> **NIH NIH R01** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 1993 · $174,834

## Abstract

Aged hearts have a reduced response to beta-adrenergic stimulation
compared to young adult hearts.  Studies from this laboratory indicate
that aged hearts produce more adenosine and have a greater interstitial
level of adenosine.  This is thought to foster an enhanced antiadrenergic
action of adenosine and, in turn, reduce the responsiveness of aged adult
hearts to beta-adrenergic stimulation.  The purpose of the proposed
project is to determine why the aged adult heart produces more adenosine
and has a higher interstitial level of the nucleoside.  Perfused rat
heart will also be used to investigate the metabolic mechanisms
responsible for the increased production of adenosine by the aging
myocardium.  The effect of aging on adenosine uptake and metabolism will
be investigated using perfused hearts.  The effect of adenosine release,
uptake and metabolism will be further studied using ventricular myocytes
and endothelial cells from aged hearts to delineate how aging affects
these processes.  This project represents a relatively new concept
involving adenosine that may be important in explaining the decrement of
beta-adrenergic responsiveness of the mammalian heart observed with
aging.

## Key facts

- **NIH application ID:** 3123415
- **Project number:** 1R01AG011491-01
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **SAM.gov UEI:** MQE2JHHJW9Q8
- **Principal Investigator:** JAMES G DOBSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $174,834
- **Award type:** 1
- **Project period:** 1993-05-01 → 1998-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3123415

## Citation

> US National Institutes of Health, RePORTER application 3123415, MECHANISMS OF AGING--ENHANCED HEART ADENOSINE (1R01AG011491-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3123415. Licensed CC0.

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