# MITOCHONDRIAL DNA MUTATION AND AGING

> **NIH NIH R01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 1993 · $166,183

## Abstract

This proposal aims to investigate the origin and mechanism of
accumulation of mitochondrial DNA damage in human tissues during aging.
In one case a specific mitochondrial DNA deletion previously found only
in patients affected with certain rare neuromuscular diseases but
recently discovered in hearts and brains of normal aged individuals will
be studied.  The goal of this research is to determine the rate these
deletions accumulate and why they accumulate to different levels in
different brain regions in aged individuals.  These studies may provide
information on the origin of mitochondrial mutations and their
contributions to aging.

## Key facts

- **NIH application ID:** 3123416
- **Project number:** 1R01AG011492-01
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **SAM.gov UEI:** G88KLJR3KYT5
- **Principal Investigator:** NORMAN ARNHEIM
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $166,183
- **Award type:** 1
- **Project period:** 1993-05-01 → 1996-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3123416

## Citation

> US National Institutes of Health, RePORTER application 3123416, MITOCHONDRIAL DNA MUTATION AND AGING (1R01AG011492-01). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3123416. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*